Left Ventricular Diastolic Function During Anesthesia Induction

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-04-01

Study Completion Date

2018-09-27

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Diastolic dysfunction is an important cause of hemodynamic instability in the perioperative field.Therefore this study aims to investigate the influence of existing diastolic dysfunction or deterioration of diastolic function on hemodynamic stability during induction of anesthesia and postoperative complications. The impact of different anesthetics on diastolic function is investigated.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Propofol Induction's Effect on Cardiac Function

NCT02408341

This Study Was Focused to Evaluate Feasibility of Doppler Tissue Monitoring During the Induction Anesthesia, and Evaluate Routine Propofol Induction's Effect on Myocardial Tissue Motion, Using Non-invasive Doppler Tissue and 2D Speckle Tracking Imaging. This is the First Study, to Our Knowledge, Which Has Evaluated the Possible Impact of Propofol Induction on LV Function.

COMPLETED

Heart Failure and Hemodynamic Stability During Anesthesia Induction

NCT03576261

Hemodynamic Instability Anesthesia; Adverse Effect Heart Failure +2 more

COMPLETED NA

Effect of Sedation Strategy on Duration Mechanical Ventilation in Patient After Cardiac Surgery

NCT05451121

Respiratory Failure Mechanical Ventilation Complication Sedation Complication

COMPLETED NA

Organ Protection With Sevoflurane Postconditioning After Cardiac Surgery With Cardiopulmonary Bypass

NCT00924222

Cardiac On-pump Surgery

COMPLETED NA

Atropine-effect During Propofol/Remifentanil Induction

NCT01871922

Anesthesia-induced Negative Hemodynamic Effects

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

In this prospective observational study two cohorts of patients with different anesthesia regimes are investigated. Anesthesia is maintained with sevoflurane or propofol. Before induction of anesthesia a transthoracic echocardiography is performed to examine systolic and diastolic function. Immediately after induction, during maintenance and after completion of anesthesia any changes of diastolic function are examined with transthoracic echocardiography. All anesthetic medications, fluids, vasoactive medications and catecholamines are registered.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Left Ventricular Diastolic Dysfunction

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Sevoflurane

Anesthesia maintenance

Sevoflurane

Intervention Type DRUG

Anesthesia maintenance with Sevoflurane

Propofol

Anesthesia maintenance

Propofol

Intervention Type DRUG

Anesthesia maintenance with Propofol

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Sevoflurane

Anesthesia maintenance with Sevoflurane

Intervention Type DRUG

Propofol

Anesthesia maintenance with Propofol

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Patients older than 60 years scheduled for general anesthesia

Exclusion Criteria

* Mitral regurgitation or stenosis \> I°
* Sp. mitral valve repair or replacement
* Pericardial effusion
* Atrial fibrillation/flutter
* Patients with pacemaker
* BMI \> 35 kg/m2

Minimum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No