Vasopressor Preload Modulation During General Anaesthesia

NCT ID: NCT05193097

Last Updated: 2022-01-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-01-03

Study Completion Date

2023-03-31

Brief Summary

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Is is debated whether administration of pure vasopressor may augment cardiac output (CO) by means of preload modulation. We wish to test this in 20 patients under general anesthesia, with preload dependency induced by head-up-tilt and preload modulation with infusion of phenylephrine. To document any changes in CO the patients will be monitored by Lithium dilution method. Furthermore we will monitor changes in peripheral perfusion index and test the ability of this non-invasive modality to track changes in CO.

Detailed Description

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Conditions

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Anesthesia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Planned surgery under general anesthesia

Exclusion Criteria

* atrial fibrillation
* refusal to participate
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Jakob Højlund

OTHER

Sponsor Role lead

Responsible Party

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Jakob Højlund

Assistant professor, consultant

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Jakob Højlund, MD

Role: PRINCIPAL_INVESTIGATOR

Hvidovre University Hospital

Central Contacts

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Jakob Højlund, MD

Role: CONTACT

References

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Hojlund J, Cihoric M, Foss NB. Vasoconstriction with phenylephrine increases cardiac output in preload dependent patients. J Clin Monit Comput. 2024 Oct;38(5):997-1002. doi: 10.1007/s10877-024-01186-7. Epub 2024 Jun 21.

Reference Type DERIVED
PMID: 38907106 (View on PubMed)

Other Identifiers

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H-21032981

Identifier Type: -

Identifier Source: org_study_id

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