A Prospective Study of Vasopressor on Cerebral Oxygenation During General Anesthesia
NCT ID: NCT06334549
Last Updated: 2024-11-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
RECRUITING
PHASE4
180 participants
INTERVENTIONAL
2024-03-05
2025-12-05
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Vasopressor Impact on Brain Circulation, Organ Blood Flow and Tissue Oxygenation During Anesthesia
NCT06083948
Preoperative Ephedrine Attenuates the Hemodynamic Responses of Propofol During Valve Surgery: A Dose Dependent Study
NCT01006863
The Effect of Epinephrine, Norepinephrine and Phenylephrine on Intraoperative Hemodynamic Performance
NCT05492968
The Effect of Blood Pressure on Cerebral Blood Flow During Propofol Anesthesia
NCT03309917
Changes in Cerebral Oxygenation During Deliberate Hypotensive Anesthesia
NCT00207987
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Ephedrine-Propofol
receive ephedrine 0.15mg/kg (configured concentration 6mg/mL) when MAP was a 20% decrease in baseline blood pressure after both induction of anesthesia and tracheal intubation.
Ephedrine-P
after induction of anesthesia, use total intravenous anesthesia maintained with propofol
Phenylephrine-propofol
receive phenylephrine 2.5ug/kg(configured concentration 100ug/mL) when MAP was a 20% decrease in baseline blood pressure after both induction of anesthesia and tracheal intubation.
Phenylephrine-P
after induction of anesthesia, use total intravenous anesthesia maintained with propofol
Norepinephrine-propofol
receive norepinephrine 0.2ug/kg(configured concentration 8μg/ml) when MAP was a 20% decrease in baseline blood pressure after both induction of anesthesia and tracheal intubation.
Norepinephrine-P
after induction of anesthesia, use total intravenous anesthesia maintained with propofol
Ephedrine-sevoflurane
receive Ephedrine 0.15mg/kg(configured concentration 6mg/mL) when MAP was a 20% decrease in baseline blood pressure after both induction of anesthesia and tracheal intubation.
Ephedrine-S
after induction of anesthesia, use inhalation anesthesia maintained with sevoflurane
Phenylephrine-sevoflurane
receive phenylephrine 2.5ug/kg(configured concentration 80ug/mL) when MAP was a 20% decrease in baseline blood pressure after both induction of anesthesia and tracheal intubation.
Phenylephrine-S
after induction of anesthesia, use inhalation anesthesia maintained with sevoflurane
Norepinephrine-sevoflurane
receive norepinephrine 0.2ug/kg(configured concentration 8ug/mL) when MAP was a 20% decrease in baseline blood pressure after both induction of anesthesia and tracheal intubation.
Norepinephrine-S
after induction of anesthesia, use inhalation anesthesia maintained with sevoflurane
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Ephedrine-P
after induction of anesthesia, use total intravenous anesthesia maintained with propofol
Phenylephrine-P
after induction of anesthesia, use total intravenous anesthesia maintained with propofol
Norepinephrine-P
after induction of anesthesia, use total intravenous anesthesia maintained with propofol
Ephedrine-S
after induction of anesthesia, use inhalation anesthesia maintained with sevoflurane
Phenylephrine-S
after induction of anesthesia, use inhalation anesthesia maintained with sevoflurane
Norepinephrine-S
after induction of anesthesia, use inhalation anesthesia maintained with sevoflurane
Other Intervention Names
Discover alternative or legacy names that may be used to describe the listed interventions across different sources.
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Elective abdominal surgery
* Signed informed consent
Exclusion Criteria
* Preoperative unstable blood hemodynamics
* Allergy to ephedrine, phenylephrine or norepinephrine
* Decrease in MAP \<20%
* Severe cardiovascular disorder
18 Years
80 Years
ALL
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Dalian Municipal Central Hospital
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Liping Han
Professor & Vice Director
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Hong Fang, MD
Role: STUDY_CHAIR
Dalian Municipal Central Hospital
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Dalian Municipal Central Hospital
Dalian, Liaoning, China
Countries
Review the countries where the study has at least one active or historical site.
Central Contacts
Reach out to these primary contacts for questions about participation or study logistics.
Facility Contacts
Find local site contact details for specific facilities participating in the trial.
Liping Han, M.D.
Role: primary
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
LSKY2023-107-01
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.