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General Anesthetic Mode and Postoperative Complications

NCT ID: NCT03335579

Last Updated: 2017-11-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

50000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-12-31

Study Completion Date

2017-10-10

Brief Summary

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The relationship between anesthetic medication and postoperative major cardiac and cerebral complications will be studied using logistic regression model.

Detailed Description

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The study group try to find out if there is a connection between the use of different anesthetic methods with different narcotic drugs and postoperative major cardiac and cerebral complications.

Conditions

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Anesthesia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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non-MACE

patients without major postoperative cardiac or cerebral complications

inhalation or propofol ,epidural or general anesthesia, remifentanil or sufentanil

Intervention Type COMBINATION_PRODUCT

Different combination of opioids and anesthetics

MACE

patients with major postoperative cardiac or cerebral complications

inhalation or propofol ,epidural or general anesthesia, remifentanil or sufentanil

Intervention Type COMBINATION_PRODUCT

Different combination of opioids and anesthetics

Interventions

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inhalation or propofol ,epidural or general anesthesia, remifentanil or sufentanil

Different combination of opioids and anesthetics

Intervention Type COMBINATION_PRODUCT

Eligibility Criteria

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Inclusion Criteria

* non-cardiac surgery, with age\> = 18 years old, ASA grade I-IV, under general anesthesia

Exclusion Criteria

* non-general anesthesia, without the use of target-controlled infusion of remifentanil or sufentanil, absence of intraoperative or perioperative information.
Minimum Eligible Age

18 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Peking University First Hospital

OTHER

Sponsor Role lead

Responsible Party

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Yan Zhou, MD

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

References

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Herling SF, Dreijer B, Wrist Lam G, Thomsen T, Moller AM. Total intravenous anaesthesia versus inhalational anaesthesia for adults undergoing transabdominal robotic assisted laparoscopic surgery. Cochrane Database Syst Rev. 2017 Apr 4;4(4):CD011387. doi: 10.1002/14651858.CD011387.pub2.

Reference Type BACKGROUND
PMID: 28374886 (View on PubMed)

Flier S, Post J, Concepcion AN, Kappen TH, Kalkman CJ, Buhre WF. Influence of propofol-opioid vs isoflurane-opioid anaesthesia on postoperative troponin release in patients undergoing coronary artery bypass grafting. Br J Anaesth. 2010 Aug;105(2):122-30. doi: 10.1093/bja/aeq111. Epub 2010 Jun 23.

Reference Type BACKGROUND
PMID: 20573633 (View on PubMed)

Min JJ, Kim G, Lee JH, Hong KY, Kim WS, Lee YT. Does the Type of Anesthetic Technique Affect In-Hospital and One-Year Outcomes after Off-Pump Coronary Arterial Bypass Surgery? PLoS One. 2016 Apr 7;11(4):e0152060. doi: 10.1371/journal.pone.0152060. eCollection 2016.

Reference Type BACKGROUND
PMID: 27054364 (View on PubMed)

Guclu CY, Unver S, Aydinli B, Kazanci D, Dilber E, Ozgok A. The effect of sevoflurane vs. TIVA on cerebral oxygen saturation during cardiopulmonary bypass--randomized trial. Adv Clin Exp Med. 2014 Nov-Dec;23(6):919-24. doi: 10.17219/acem/37339.

Reference Type BACKGROUND
PMID: 25618118 (View on PubMed)

Other Identifiers

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GATCIMACE

Identifier Type: -

Identifier Source: org_study_id