The Effect of Propofol Infusion on Total Antioxidant Status During Tourniquet-Induced Ischemia-Reperfusion Injury
NCT ID: NCT01638624
Last Updated: 2016-06-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE4
36 participants
INTERVENTIONAL
2012-06-30
2012-11-30
Brief Summary
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Plasma total antioxidant capacity is a well-established marker of the overall protective effect of antioxidants in body fluids.The aim of the study is to investigate the effects of propofol on ischemia-reperfusion injury in total knee arthroplasty (TKA).
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
DOUBLE
Study Groups
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Propofol
Propofol infusion group: Under spinal anesthesia, a continuous intravenous infusion (2mg/kg/h) of propofol will be use during the operation
Propofol
Propofol :Propofol is an anesthetic agent, has structure similar to that of known such as alfa tocopherol.
Control group
Placebo group: Under spinal anesthesia, a continuous intravenous infusion of volume-equivalent placebo will use during the operation
Placebo
Interventions
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Propofol
Propofol :Propofol is an anesthetic agent, has structure similar to that of known such as alfa tocopherol.
Placebo
Eligibility Criteria
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Inclusion Criteria
* Unilateral total knee arthroplasty
* Age 18 years to 80 years
Exclusion Criteria
* Severe cardiopulmonary,renal,metabolic, or hepatic disease,
* Blood volume deficits,
* Coagulopathy,
* Allergy to local anesthetics,
* Peripheral neuropathies,
* Body mass index \> 35,
* History of antioxidant drug use
18 Years
80 Years
ALL
No
Sponsors
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Diskapi Teaching and Research Hospital
OTHER
Responsible Party
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derya özkan
Consultant MD of Anesthesiology Department
Principal Investigators
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Derya Özkan, MD
Role: PRINCIPAL_INVESTIGATOR
Ministry of health Diskapi Yıldirim Beyazit Training and Research Hospital Anesthesiology Clinic
Taylan Akkaya, MD
Role: STUDY_CHAIR
Ministry of health Diskapi Yıldirim Beyazit Training and Research Hospital Anesthesiology Clinic
Ali Yalcindag, MD
Role: STUDY_CHAIR
Ministry of health Diskapi Yıldirim Beyazit Training and Research Hospital Biochemistry Clinic
Tuba Hanci, MD
Role: STUDY_CHAIR
Ministry of health Diskapi Yıldirim Beyazit Training and Research Hospital Biochemistry Clinic
Haluk Gümüs, MD
Role: STUDY_CHAIR
Ministry of health Diskapi Yıldirim Beyazit Training and Research Hospital Anesthesiology Clinic
Namik Delibas, MD
Role: STUDY_CHAIR
Ministry of health Diskapi Yıldirim Beyazit Training and Research Hospital Biochemistry Clinic
Emel Gönen, Consultant
Role: STUDY_CHAIR
Ministry of health Diskapi Yıldirim Beyazit Training and Research Hospital Orthopedics Clinic
Locations
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Ministry of health Diskapi Yıldirim Beyazit Training and Research Hospital Anesthesiology and Biochemistry Clinics
Ankara, , Turkey (Türkiye)
Countries
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Other Identifiers
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Diskapi2012
Identifier Type: -
Identifier Source: org_study_id
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