Protective Effect of Propofol Against Hemolysis in Patients Submitted to Gastroplasty

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-11-30

Study Completion Date

2009-06-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to determine if propofol could protect erythrocytes by directly scavenging free radicals from the blood current and increasing resistance of their cell membranes in patients submitted to gastroplasty.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Propofol Pharmacokinetics and Pharmacodynamics During Cardiopulmonary Bypass

NCT00622791

Coronary Artery Disease Cardiopulmonary Bypass Coronary Artery Bypass Graft

COMPLETED

Toxicogenomic and Immunocytotoxic Effects of Propofol and Isoflurane Anesthetics in Patients Undergoing Elective Surgery

NCT00854178

Patients in Good Health Types of General Anesthesia DNA Damage

COMPLETED PHASE4

The Effect of Propofol Infusion on Total Antioxidant Status During Tourniquet-Induced Ischemia-Reperfusion Injury

NCT01638624

Total Knee Arthroplasty Tourniquet-Induced Ischemia-Reperfusion Injury

COMPLETED PHASE4

Effects of Desflurane Versus Propofol on Hemostasis During Splenectomy

NCT02079064

Status; Splenectomy

COMPLETED NA

Blood Sampling Pre- and Post-Propofol Administration to Characterize the Blood Proteome Using Different Research Assays

NCT07295795

Critically Ill Surgical Patients

NOT_YET_RECRUITING

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Hemolysis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Propofol

Patients in the Propofol Group (PG) will be induced with target-controlled infusion (TCI) of propofol (Diprifusor, AstraZeneca) and remifentanil (Asena PK, Cardinal Health) at the target dose of 6.0 µg.ml-1 and 8.0 ηg.ml-1, respectively. The patients in the Sevoflurane Group (SG) will be induced with remifentanil TCI at target dose of 8.0 ηg.ml-1 and etomidate 0.5 mg.kg-1 in bolus.

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* patients between BMI 40-50 kg/m2

Exclusion Criteria

* patients with BMI under 40 kg/m2 and over 50 kg/m2
* alcohol users
* illicit-drug users
* patients in regular use of anti-depressants, proton bomb inhibitors or calcium canal blockers
* patients transfused either recently, during the intra-operative period or within 10 hours post-operative
* patients previously known to be hypersensitive to any drug that is used during the study
* patients with any psychiatric disorder or dementia

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No