Propofol Pharmacokinetics and Pharmacodynamics During Cardiopulmonary Bypass
NCT ID: NCT00622791
Last Updated: 2008-02-25
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
20 participants
OBSERVATIONAL
Brief Summary
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Twenty undergoing coronary artery bypass graft patients will be allocated in two groups: 1) CPB groups and 2) off-pump coronary artery bypass graft. Bispectral Index values and blood samples for plasma propofol concentration measurements will be collected along the surgery and up to 12 hours in the post-operative period. Plasma propofol concentrations, Bispectral index values and propofol PK will be compared between the groups.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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CABG group
Patients undergoing coronary artery bypass graft with cardiopulmonary bypass
No interventions assigned to this group
OPCAB group
Patients undergoing off-pump coronary artery bypass graft
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Left ventricular ejection fraction greater than 50 %
* Absence of preoperative pulmonary dysfunction
Exclusion Criteria
* Postoperative pulmonary dysfunction
18 Years
80 Years
ALL
No
Sponsors
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Fundação de Amparo à Pesquisa do Estado de São Paulo
OTHER_GOV
University of Sao Paulo
OTHER
Responsible Party
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Faculdade de Medicina da Universidade de São Paulo
Principal Investigators
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Maria M Carmona, MD PhD
Role: PRINCIPAL_INVESTIGATOR
Faculdade de Medicina da Universidade de São Paulo
Locations
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Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
São Paulo, São Paulo, Brazil
Countries
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References
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Barbosa RA, Santos SR, White PF, Pereira VA, Silva Filho CR, Malbouisson LM, Carmona MJ. Effects of cardiopulmonary bypass on propofol pharmacokinetics and bispectral index during coronary surgery. Clinics (Sao Paulo). 2009;64(3):215-21. doi: 10.1590/s1807-59322009000300012.
Other Identifiers
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802-01
Identifier Type: -
Identifier Source: org_study_id
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