Pharmacokinetic and -Dynamic of Propofol During Awake Craniotomy
NCT ID: NCT01128465
Last Updated: 2011-03-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
10 participants
OBSERVATIONAL
2010-02-28
Brief Summary
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The aim of the study is to investigate whether the pk/pd model proposed by Marsh et al. or by Schnider et al. more accurately describe the pk/pd of propofol during awake craniotomy.
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Detailed Description
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Conditions
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Study Design
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CASE_ONLY
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
18 Years
ALL
No
Sponsors
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University Hospital, Bonn
OTHER
Responsible Party
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Dept. of Anaesthesiology and Intensive Care Medicine
Principal Investigators
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Martin Soehle, MD, DESA, D habil
Role: PRINCIPAL_INVESTIGATOR
Dept. of Anaesthesiology and Intensive Care Medicine, University of Bonn, Germany
Locations
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Dept. of Anaesthesiology and Intensive Care Medicine, Univ. of Bonn
Bonn, , Germany
Countries
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References
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Schnider TW, Minto CF, Gambus PL, Andresen C, Goodale DB, Shafer SL, Youngs EJ. The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers. Anesthesiology. 1998 May;88(5):1170-82. doi: 10.1097/00000542-199805000-00006.
Marsh B, White M, Morton N, Kenny GN. Pharmacokinetic model driven infusion of propofol in children. Br J Anaesth. 1991 Jul;67(1):41-8. doi: 10.1093/bja/67.1.41.
Soehle M, Wolf CF, Priston MJ, Neuloh G, Bien CG, Hoeft A, Ellerkmann RK. Comparison of propofol pharmacokinetic and pharmacodynamic models for awake craniotomy: A prospective observational study. Eur J Anaesthesiol. 2015 Aug;32(8):527-34. doi: 10.1097/EJA.0000000000000255.
Other Identifiers
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AC
Identifier Type: -
Identifier Source: org_study_id
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