Propofol-remifentanyl Versus Dexmedetomidine in Awake Craniotomy: Impact on Electroclinical Seizure Activity
NCT ID: NCT05103735
Last Updated: 2023-01-31
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
170 participants
OBSERVATIONAL
2021-09-15
2021-10-11
Brief Summary
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Neurosurgeon could be help by Intraoperative electrocorticography to maximise lesion resection and avoiding neurologic sequelae. Propofol and remifentanyl have been largely used. Dexmedetomidine represents an alternative. However little is known about the role of dexmedetomidine on Intraoperative electrocorticography.
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Detailed Description
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Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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PROPOFOL-REMIFENTANYL
Awake craniotomy under propofol-remifentanil sedation. Propofol and remifentanyl was administered through continuous intravenous infusion, starting 30 minutes prior to surgery. The end of the infusion was at the end of the surgical procedure.
Propofol dosage: 0.2-2 mk/kg/h Remifentanyl dosage: 0.01-0.1 mcg/kg/min
Propofol
awake neurosurgery under propofol-remifentanil sedation
DEXMEDETOMIDINE
Awake craniotomy under dexmedetomidine sedation. Dexmedetomidine was administered through continuous intravenous infusion, starting 30 minutes prior to surgery. The end of the infusion was at the end of the surgical procedure.
Dexmedetomidine dosage: 0.2-1 mcg/kg/h In this group, remifentanyl administration was allowed.
No interventions assigned to this group
Interventions
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Propofol
awake neurosurgery under propofol-remifentanil sedation
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* INTRAOPERATIVE MONITORING (IOM) WITH ELECTROCORTICOGRAPHY
* AWAKE-AWAKE-AWAKE TECHNIQUE
Exclusion Criteria
* NON AWAKE-AWAKE-AWAKE TECHNIQUE
* ABSENCE OF IOM
18 Years
ALL
No
Sponsors
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Azienda Sanitaria-Universitaria Integrata di Udine
OTHER
Responsible Party
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Cristian Deana
Principal Investigator
Locations
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Cristian Deana
Udine, , Italy
Countries
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References
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Deana C, Pez S, Ius T, Furlan D, Nilo A, Isola M, De Martino M, Mauro S, Verriello L, Lettieri C, Tomasino B, Valente M, Skrap M, Vetrugno L, Pauletto G. Effect of Dexmedetomidine versus Propofol on Intraoperative Seizure Onset During Awake Craniotomy: A Retrospective Study. World Neurosurg. 2023 Apr;172:e428-e437. doi: 10.1016/j.wneu.2023.01.046. Epub 2023 Jan 20.
Other Identifiers
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CRANIO-UDINE
Identifier Type: -
Identifier Source: org_study_id
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