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Differential Effects of Propofol on Scalp and Intracranial EEG

NCT ID: NCT02995447

Last Updated: 2017-12-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

15 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-11-30

Study Completion Date

2018-12-31

Brief Summary

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The anesthetic propofol has a dose-depending effect on the EEG, which differs in comparison between scalp and intracerebral electrodes

Detailed Description

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The electrical activity of the brain (electroencephalogram EEG) is usually assessed from the surface of the head, which is approximately 1-2 cm above the cerebral cortex. Thus, the spatial resolution of the EEG is low, and the electrical activity recorded originates from a multitude of neurons.

Deep brain structures such as the hippocampus also generate electrical activity which cannot be assessed from the surface of the head. However, in some patients electrodes are implanted into the brain to look for the origin of epileptic seizures. Along the way, these intracerebral electrodes enable to record the EEG from intracerebral structures which are generated from few neurons only. Once the origin of epilepsy has been identified, the intracerebral electrodes are removed under general anesthesia.

Anesthetics such as propofol characteristically modify the EEG in a dose-dependant manner. More over, the propofol effect on the EEG recorded from the surface is likely to be different from the intracerebral EEG, however little is known so far. Therefore we aim to investigate the differential effect of propofol on the superficial versus intracerebral recorded EEG.

Conditions

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General Anesthesia

Keywords

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propofol electroencephalogram

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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epilepsy patients

The group consists of patients with therapy refractory epilepsy, in which intracerebral electrodes were implanted to locate the seizure origin and to determine whether the patients are eligible for epilepsy surgery. In an observational study, differences between surface and intracerebral EEG are recorded.

differences between surface and intracerebral EEG

Intervention Type OTHER

No intervention is performed. Im- and explantation of intracerebral electrodes is performed for clinical and not for study purposes. The only difference between study and non-study patients is that the surface as well as the intracerebral EEG is recorded and stored in the former, while it is discarded in the latter.

Interventions

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differences between surface and intracerebral EEG

No intervention is performed. Im- and explantation of intracerebral electrodes is performed for clinical and not for study purposes. The only difference between study and non-study patients is that the surface as well as the intracerebral EEG is recorded and stored in the former, while it is discarded in the latter.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients with implanted intracerebral EEG electrodes

Exclusion Criteria

* Pregnancy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Bonn

OTHER

Sponsor Role lead

Responsible Party

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Martin Soehle

Consultant

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Martin Soehle, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Dept. of Anesthesiology and Intensive Care Medicine

Locations

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Dept. of Anaesthesiology and Intensive Care Medicine, University of Bonn

Bonn, , Germany

Site Status RECRUITING

Countries

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Germany

Central Contacts

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Martin Soehle, MD, PhD

Role: CONTACT

Phone: ++49-228-287-

Email: [email protected]

Florian Mormann, MD, PhD

Role: CONTACT

Phone: ++49-228-287-

Email: [email protected]

Facility Contacts

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Martin Soehle, MD, PhD

Role: primary

Florian Mormann, MD, PhD

Role: backup

Other Identifiers

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EPI_12

Identifier Type: -

Identifier Source: org_study_id