EEG Spectrogram-guided vs. Index-guided Anesthesia for Craniotomy
NCT ID: NCT06244017
Last Updated: 2024-02-07
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
120 participants
INTERVENTIONAL
2024-02-29
2026-02-28
Brief Summary
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Detailed Description
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For instance, dexmedetomidine (DEX) is currently one of the most commonly used drugs in multimodal generagal anesthesia.Because each anesthetic produces distinct brain states that are readily visible in an EEG density spectral array (DSA) and can be easily interpreted by anesthesiologists, anesthetic titration based on an EEG DSA may provide additional information for anesthetic depth monitoring and may avoid the conventional 'one-index-fits-all' approach, which often ignores the influence of anesthetic drug combination. Theoretically, the anesthetic exposure in cases that involve the coadministration of dexmedetomidine can be more precise through the use of an EEG DSA than the use of BIS value. In accordant to this context, investigators have changed our institutional anesthetic propofol from BIS guidance to the DSA guidance and based on the retrospective analysis, investigators further observed the profound anesthetic-sparing effects and potential postoperative benefits of EEG DSA-guided anesthesia comparing to the BIS-guided anesthesia (doi: 10.4097/kja.23118). Therefore, further prospective randomized controlled is warranted to shape the real clinical benefits of DSA-guided multimodal general anesthesia.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
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EEG Spectrogram-guided
The general anesthesia administration is guided by using the EEG spectrogram in this group. Other perioperative care protocols are the same between the two study group.
EEG spectrogram
In the experimental group, the general anesthesia is guided by using the EEG spectrogram.
Bispectral index-guided
The general anesthesia administration is guided by using the processed EEG index, namely the bispectral index (BIS) in this group. Other perioperative care protocols are the same between the two study group.
Bispectral index
In the control group, the general anesthesia is guided by using the bispectral index
Interventions
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EEG spectrogram
In the experimental group, the general anesthesia is guided by using the EEG spectrogram.
Bispectral index
In the control group, the general anesthesia is guided by using the bispectral index
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* heart failure
* liver cirrhosis \> Child B class
* chronic obstructive pulmonary disease
20 Years
ALL
No
Sponsors
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National Taiwan University Hospital
OTHER
Responsible Party
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Principal Investigators
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Chun-Yu Wu
Role: PRINCIPAL_INVESTIGATOR
National Taiwan University Hospital Hsinchu Branch
Locations
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National Taiwan University Hospital
Taipei, , Taiwan
Countries
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Central Contacts
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Facility Contacts
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Chun-Yu Wu
Role: primary
Other Identifiers
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202312067DINA
Identifier Type: -
Identifier Source: org_study_id
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