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Desflurane and Brain Relaxation in Craniotomy

NCT ID: NCT04691128

Last Updated: 2021-10-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

111 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-01-26

Study Completion Date

2021-08-31

Brief Summary

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Optional brain relaxation improves the surgeon's operating conditions and is likely to minimize the degree of retraction injury ,with the potential for providing patients with a better outcome. The choice of anesthetic drugs can affect intraoperative brain relaxation. Propofol suppresses brain metabolism, reduces cerebral blood flow, and provides satisfactory brain relaxation. Desflurane is often criticized in neurosurgery due to its cerebral vasodilation and potential to increase intracranial pressure, however, it has been found to have a little clinical significance. This study intends to compare the effects of desflurane with propofol on brain relaxation in patients with supratentorial tumors under mild hyperventilation, and to provide new clinical evidence for the use of desflurane in neurosurgical anesthesia.

Detailed Description

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To compare the effect of desflurane versus propofol combined with remifentanil anesthesia on brain relaxation in patients undergoing supratentorial tumor surgery with mild hyperventilation, and compare the emergence time and common complications during recovery.

Conditions

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Supratentorial Tumor

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Desflurane inhalational anesthesia

Group Type EXPERIMENTAL

Desflurane

Intervention Type DRUG

After induction, anesthesia will be maintained with 0.8-1.3 MAC desflurane and 0.05-0.2 μg/kg/min remifentanil.

Propofol total intravenous anesthesia

Group Type ACTIVE_COMPARATOR

Propofol

Intervention Type DRUG

After induction, anesthesia will be maintained with 6-8 mg/kg/h propofol and 0.05- 0.2 μg/kg/min remifentanil

Interventions

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Desflurane

After induction, anesthesia will be maintained with 0.8-1.3 MAC desflurane and 0.05-0.2 μg/kg/min remifentanil.

Intervention Type DRUG

Propofol

After induction, anesthesia will be maintained with 6-8 mg/kg/h propofol and 0.05- 0.2 μg/kg/min remifentanil

Intervention Type DRUG

Other Intervention Names

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inhalational anesthesia TIVA total intravenous anesthesia

Eligibility Criteria

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Inclusion Criteria

* 18-60 years
* Scheduled for elective craniotomy for supratentorial cerebral tumors
* ASA status I-III
* Glasgow score of 15
* No clinical signs of intracranial hypertension
* Preoperative brain imaging (CT or MRI) with midline shift less than 5mm
* Informed consent signed by patients

Exclusion Criteria

* Scheduled intraoperative motor evoked potential monitoring
* Patients with cerebral vascular diseases
* Uncontrolled cardiopulmonary disease
* Schedule to retain tracheal intubation after surgery
* Unable to comprehend and cooperate with the examination
* BMI \> 30 Kg/m-2
* Emergency surgery
* History of related anesthetic allergy
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Beijing Tiantan Hospital

OTHER

Sponsor Role lead

Responsible Party

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Ruquan Han

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Beijing Tiantan Hospital, Capital Medical University

Beijing, Beijing Municipality, China

Site Status

Countries

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China

References

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Jiang Z, Wu Y, Liang F, Jian M, Liu H, Mei H, Han R. Brain relaxation using desflurane anesthesia and total intravenous anesthesia in patients undergoing craniotomy for supratentorial tumors: a randomized controlled study. BMC Anesthesiol. 2023 Jan 10;23(1):15. doi: 10.1186/s12871-023-01970-z.

Reference Type DERIVED
PMID: 36624384 (View on PubMed)

Other Identifiers

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H199510180629

Identifier Type: -

Identifier Source: org_study_id