Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
100 participants
OBSERVATIONAL
2010-01-31
2013-02-28
Brief Summary
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The aim of this study is to evaluate plasma concentrations of propofol in relation to depth of anesthesia, measured by continuous EEG and to correlate plasma concentrations with genetic analyses of liver enzymes responsible for drug elimination.
Our hypothesis is that there is an individual requirement of Propofol plasma concentration depending on genetic differences in drug elimination.
200 patients, ASA classification 1, planned for elective surgery of a duration of at least 30 minutes will be included in this study.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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200 patients,ASA 1
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* (ASAclassification 1) planned for elective surgery,
* with body mass index 20-30,
* free from analgetic drug \> 12 hours prior to anesthesia
Exclusion Criteria
* Smoking,
* allergy to propofol or peanuts,
* alcohol abuse,
* non-caucasian
18 Years
50 Years
ALL
No
Sponsors
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University Hospital, Linkoeping
OTHER
Responsible Party
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Anna Oscarsson
Dr
Locations
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Department of Anesthesia and Intensive Care
Kalmar, , Sweden
Countries
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References
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Khan MS, Zetterlund EL, Green H, Oscarsson A, Zackrisson AL, Svanborg E, Lindholm ML, Persson H, Eintrei C. Pharmacogenetics, plasma concentrations, clinical signs and EEG during propofol treatment. Basic Clin Pharmacol Toxicol. 2014 Dec;115(6):565-70. doi: 10.1111/bcpt.12277. Epub 2014 Jul 19.
Other Identifiers
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Progen1
Identifier Type: -
Identifier Source: org_study_id
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