Monitoring Exhaled Propofol to Individualize General Anesthesia

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-08-31

Study Completion Date

2010-10-31

Brief Summary

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This trial investigates the relationship between concentrations of the anesthetic drug propofol in exhaled breath, blood and drug effect in volunteers undergoing general anesthesia. The main goal of this study is to develop a pharmacokinetic - and dynamic model for propofol in exhaled breath.

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Detailed Description

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Conditions

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General Anesthesia

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Blinding Strategy

SINGLE

Participants

Study Groups

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Propofol

Volunteers will receive propofol anesthesia on the study day.

Group Type OTHER

Propofol Anesthesia

Intervention Type DRUG

Volunteers will undergo propofol anesthesia for 90 min.

Interventions

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Propofol Anesthesia

Volunteers will undergo propofol anesthesia for 90 min.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* 18 years of age

* Written informed consent
* Ability and willingness to give written informed consent
* American Society of Anesthesiologists (ASA) risk score I

Exclusion Criteria

* Volunteers ASA physical status II - III
* Pregnancy
* Volunteers with history of neurological disease or stroke
* Volunteers with a history of recreational drug abuse
* Volunteers with a history of alcohol abuse
* Smokers
* Anesthesia within 6 months
* Known drug allergies
* History of adverse events during general anesthesia

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes