The Acute Effects of Exercise and Caffeine on Working Memory During Acute Caffeine Deprivation

NCT ID: NCT05170464

Last Updated: 2024-03-04

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE2/PHASE3
• Total Enrollment: 7 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-01-10
• Study Completion Date: 2022-04-01

Brief Summary

To determine the effects of moderate intensity exercise and caffeine on working memory in deprived caffeine consumers.

Detailed Description

Participants will be asked to keep consumption of caffeine before the first visit to their regular dose (ex. morning coffee) and to abstain from alcohol and drugs for at least 18 hours prior to testing. Participants will be urged to arrive at the same time for each visit. Upon arrival to the Exercise and Health Psychology lab (located in room 408 of the Arthur and Sonia Labatt Health Science Building at Western University) participants will be given the letter of information and asked to sign the informed consent form. Participants will also be asked to complete a demographic survey, PAR-Q (Physical Activity Readiness Questionnaire) readiness for exercise, Godin Leisure-Time Exercise Questionnaire, CCQ-R (Caffeine Consumption Questionnaire), and the CWSQ (Caffeine Withdrawal Symptom Questionnaire). Vitals (heart rate and blood pressure) will be assessed following the completion of the questionnaires as well as post assessment in the seated position. Prior to evaluation on the N-back task (cognitive memory task described below) a practice stage with be conducted until the participant can consistently score 75% or higher on three consecutive trials to eliminate a learning effect. After establishing familiarity, a baseline cognition score will be conducted through the n-back assessment.

Prior to arrival for the second visit, participants will be asked to refrain from caffeine for at least 24 hours and to abstain from abstain from alcohol and drugs for at least 18 hours prior to testing. During the second visit (approximately 24 hours after the first) the participants will complete the pre-caffeine or pre-exercise questionnaire, the CWSQ and vitals will be monitored pre and post intervention. Caffeine abstinence will be validated through self-report with the use of deception (participants being told that their saliva sample is being tested for the presence of caffeine). To collect saliva, a cotton swab will be placed under their tongue for 1minute, placed into a tube, and then a co-investigator will discard the tube into a biohazard deposal container immediately. Participants will then complete another n-back assessment.

The participants will be randomized into either the moderate intensity exercise or caffeine ingestion group. The interventions are as followed; Moderate Intensity Exercise will consist of a 20-minute bout of moderate intensity aerobic exercise. Exercise will consist of a 2-minute warm-up, followed by 15 minutes of walking at a rate, which will allow you to reach 2/3 of your max heart rate (moderate intensity exercise= (220-age) x 0.6), and then a 3-minute cool down on a treadmill (together equaling 20 minutes). HR will be monitored through heart rate monitors worn by the participants. The caffeine ingestion group will ingest 1.2 mg/kg of caffeine in powder form with water to drink, after ingestion of caffeine participants will wait 20 minutes to ensure peak plasma levels. The post intervention n-back assessment will begin within two minutes of the completion of either intervention.

Conditions

Acute Exercise; Caffeine Withdrawal; Memory Deficits

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Acute Exercise

20 minutes of moderate intensity acute exercise (treadmill speed to achieve ⅔ of maximum heart rate).

Group Type: EXPERIMENTAL

Acute Exercise

Intervention Type: BEHAVIORAL

Brisk walking on a treadmill at ⅔ maximum heart rate as defined by 220-age (in years).

Caffeine Ingestion

1.2mg/kg of powdered caffeine (Caffeine powder, ReagentPlus® from Sigma-Aldrich) dissolved in 1 cup of water then sitting for 20 minutes.

Group Type: ACTIVE_COMPARATOR

Caffeine Powder

Intervention Type: DRUG

Participants will receive powdered caffeine dissolved in one cup of water (1.2mg/kg)

Interventions

Acute Exercise

Brisk walking on a treadmill at ⅔ maximum heart rate as defined by 220-age (in years).

Intervention Type: BEHAVIORAL

Caffeine Powder

Participants will receive powdered caffeine dissolved in one cup of water (1.2mg/kg)

Intervention Type: DRUG

Other Intervention Names

Aerobic Exercise; Caffeine Ingestion

Eligibility Criteria

Inclusion Criteria

• Are over the age of 18 years
• Consume at least 150 mg of caffeine a day
• Do not have any cognitive problems
• Are not pregnant
• Do not have a medical condition that prevents you to exercise
• Do not have an orthopaedic limitation
• Have access to a telephone or an email account for communication
• Can read and write in English

Exclusion Criteria

• Participants taking prescription medication for depression or anxiety
• Participants that cannot give informed consent will be excluded.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Western University, Canada

OTHER

Sponsor Role: lead

Responsible Party

Dr. Harry Prapavessis

Professor, School of Kinesiology

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Harry Prapavessis, PhD

Role: PRINCIPAL_INVESTIGATOR

Western University

Locations

The University of Western Ontario

London, Ontario, Canada

Countries

Canada

References

Morava A, Fagan MJ, Prapavessis H. Effects of Caffeine and Acute Aerobic Exercise on Working Memory and Caffeine Withdrawal. Sci Rep. 2019 Dec 23;9(1):19644. doi: 10.1038/s41598-019-56251-y.

Reference Type: BACKGROUND

PMID: 31873185 (View on PubMed)

Other Identifiers

120038

Identifier Type: -

Identifier Source: org_study_id