Caffeine Increases Maximal Fat Oxidation During Exercise in Endurance-trained Men: is There a Diurnal Variation

NCT ID: NCT04320446

Last Updated: 2020-03-25

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 15 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2019-06-01
• Study Completion Date: 2019-11-30

Brief Summary

Maximal fat oxidation during exercise (MFO) and the intensity of exercise that elicits MFO (Fatmax) has been recognized as potential determinants of endurance performance.

The purpose of this study was to determine the possible interaction between the effects of diurnal variation (morning vs. afternoon) and caffeine ingestion on MFO, Fatmax and VO2 max in endurance-trained men. Specifically, the investigators sought to elucidate whether the stimulant actions of caffeine could reverse the decrements of MFO and Fatmax observed in the morning.

Detailed Description

Body weight, height, body composition (DXA), exercise test (MFO and VO2max assessment) will be measured during the 4 evaluations.

Participants were randomized into 4 exercise test conditions:

1. Exercise test in the morning with placebo intake

2. Exercise test in the evening with placebo intake

3. Exercise test in the morning with caffeine intake

4. Execrise test in the evening with caffeine intake

Conditions

Energy Metabolism; Athletic Performance

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: OTHER
• Blinding Strategy: TRIPLE

Study Groups

Caffeine

A dose of 3 mg/kg of caffeine (i.e. a vegetable extraction from green coffee beans, Harrison Sport Nutrition®, Spain) was ingested before the beginning of each test.

Group Type: EXPERIMENTAL

Test in the morning

Intervention Type: BEHAVIORAL

The exercise test was performed between 8 a.m and 11 a.m

Test in the afternoon

Intervention Type: BEHAVIORAL

The exercise test was performed between 5 p.m. and 8 p.m.a

Placebo

A dose of 3 mg/kg of placebo (i.e. 100% purity microcrystalline cellulose, Acofarma, Spain) was ingested before the beginning of each test.

Group Type: PLACEBO_COMPARATOR

Test in the morning

Intervention Type: BEHAVIORAL

The exercise test was performed between 8 a.m and 11 a.m

Test in the afternoon

Intervention Type: BEHAVIORAL

The exercise test was performed between 5 p.m. and 8 p.m.a

Interventions

Test in the morning

The exercise test was performed between 8 a.m and 11 a.m

Intervention Type: BEHAVIORAL

Test in the afternoon

The exercise test was performed between 5 p.m. and 8 p.m.a

Intervention Type: BEHAVIORAL

Other Intervention Names

MFO-morning, Fatmax-morning, and VO2max-morning; (MFO-afternoon, Fatmax-afternoon, and VO2max-afternoon

Eligibility Criteria

Inclusion Criteria

• Having a body mass index (BMI) ranged from 18.5 to 28 kg/m2
• not suffering any specific disease which can be aggravated by physical exercise
• having previous experience in endurance training (i.e. self-reporting at least 2 years of cycling or running training including more than 3 training sessions/week).

Exclusion Criteria

• Being smoker
• Taking medication or drugs
• Any non-controlled medical condition which could influence results or could be worsened by the participation in the study
• Are deemed unsuitable by the investigator for any other reason, that prevent data collection.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 40 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

Universidad de Granada

OTHER

Sponsor Role: lead

Responsible Party

Jonatan Ruiz Ruiz

Associate professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Jonatan Ruiz Ruiz, Dr.

Role: PRINCIPAL_INVESTIGATOR

Universidad de Granada

Locations

Instituto Mixto Universitario Deporte Salud

Granada, , Spain

Countries

Spain

References

Ramirez-Maldonado M, Jurado-Fasoli L, Del Coso J, R Ruiz J, Amaro-Gahete FJ. Caffeine increases maximal fat oxidation during a graded exercise test: is there a diurnal variation? J Int Soc Sports Nutr. 2021 Jan 7;18(1):5. doi: 10.1186/s12970-020-00400-6.

Reference Type: DERIVED

PMID: 33413459 (View on PubMed)

Other Identifiers

Nº 507/CEIH/2018

Identifier Type: -

Identifier Source: org_study_id