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Effect of Caffeine on Myocardial Oxygenation

NCT ID: NCT04585854

Last Updated: 2021-10-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

29 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-11-13

Study Completion Date

2021-10-23

Brief Summary

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The purpose of this study is to investigate the impact of caffeine on myocardial oxygenation and other cardiovascular magnetic resonance parameters in healthy controls.

Detailed Description

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Caffeine is presumed to create a confounder with diagnostic imaging. The vasodilatory capacity is considered a key measure for the detection of significant coronary disease with stenosed epicardial arterial conduit vessels and overall microvascular function, including endothelial dysfunction. Twenty nine healthy controls will undergo a baseline cardiovascular magnetic resonance (CMR) exam. Afterwards, participants will consume coffee in the presence of study personnel. This will consist of 3 espresso shots, which will be consumed within 15 minutes. Approximately 2h after coffee consumption the CMR exam will be repeated. The goal will be to investigate the impact of caffeine on myocardial features. In particular the effect on the myocardial oxygenation response to vasodilating and vasoconstricting stimuli.

Conditions

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Caffeine

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Controlled before-after comparison
Primary Study Purpose

OTHER

Blinding Strategy

NONE

Blinded image analysis

Study Groups

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Control

Control population who will undergo two cardiovascular magnetic resonance exams: one at rest and one after drinking caffeine.

Group Type OTHER

Caffeine

Intervention Type OTHER

Consumption of 3 shots of espresso

Interventions

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Caffeine

Consumption of 3 shots of espresso

Intervention Type OTHER

Other Intervention Names

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Coffee

Eligibility Criteria

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Inclusion Criteria

* Ability to give informed consent, documented by signature
* Aged 18 to 45

Exclusion Criteria

* MRI Contraindications following current institutional guidelines at the time of the CMR exam
* Knowledge or suspicion of pregnancy (verified with a pregnancy test).
* Consumption of caffeine 12h prior to the baseline CMR exam (outside of the study protocol).
* Known cardiovascular disease, diabetes, severe respiratory disease, obstructive sleep apnea syndrome, chemotherapy and radiation treatment, cerebrovascular and occlusive peripheral vascular disease.
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Insel Gruppe AG, University Hospital Bern

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Dominik P Guensch, MD

Role: PRINCIPAL_INVESTIGATOR

Bern University Hospital, Inselspital

Locations

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Bern University Hospital, Inselspital

Bern, , Switzerland

Site Status

Countries

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Switzerland

References

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Fischer K, Yamaji K, Luescher S, Ueki Y, Jung B, von Tengg-Kobligk H, Windecker S, Friedrich MG, Eberle B, Guensch DP. Feasibility of cardiovascular magnetic resonance to detect oxygenation deficits in patients with multi-vessel coronary artery disease triggered by breathing maneuvers. J Cardiovasc Magn Reson. 2018 May 7;20(1):31. doi: 10.1186/s12968-018-0446-y.

Reference Type BACKGROUND
PMID: 29730991 (View on PubMed)

van Dijk R, Ties D, Kuijpers D, van der Harst P, Oudkerk M. Effects of Caffeine on Myocardial Blood Flow: A Systematic Review. Nutrients. 2018 Aug 13;10(8):1083. doi: 10.3390/nu10081083.

Reference Type BACKGROUND
PMID: 30104545 (View on PubMed)

Kuijpers D, Prakken NH, Vliegenthart R, van Dijkman PR, van der Harst P, Oudkerk M. Caffeine intake inverts the effect of adenosine on myocardial perfusion during stress as measured by T1 mapping. Int J Cardiovasc Imaging. 2016 Oct;32(10):1545-53. doi: 10.1007/s10554-016-0949-2. Epub 2016 Jul 29.

Reference Type BACKGROUND
PMID: 27473274 (View on PubMed)

Other Identifiers

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2020-01876

Identifier Type: -

Identifier Source: org_study_id