Reproducibility of Acute Caffeine Effect

NCT ID: NCT06606639

Last Updated: 2025-05-25

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 48 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-01-08
• Study Completion Date: 2024-05-22

Brief Summary

Introduction: Various studies have evaluated and verified the ergogenic effect of acute caffeine intake on sports performance, specifically on strength and power performance. However, all experimental investigations designed so far have been based on the comparison of the "caffeine" and "placebo" conditions in a single trial, not considering the reproducibility and variability of caffeine in multiple trials.

Objectives: The present study aims to evaluate the reproducibility and replicability of the acute effect of caffeine intake on energy metabolism and the muscular production of force, power and endurance, according to sex (men vs women) and type of exercise ( bench press vs squat).

Conditions

Caffeine and Resistance Exercise

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: OTHER
• Blinding Strategy: DOUBLE

Study Groups

Caffeine - Trial 1

Group Type: EXPERIMENTAL

Caffeine

Intervention Type: DIETARY_SUPPLEMENT

acute caffeine intake (3 mg/kg)

Caffeine - Trial 2

Group Type: EXPERIMENTAL

Caffeine

Intervention Type: DIETARY_SUPPLEMENT

acute caffeine intake (3 mg/kg)

Caffeine - Trial 3

Group Type: EXPERIMENTAL

Caffeine

Intervention Type: DIETARY_SUPPLEMENT

acute caffeine intake (3 mg/kg)

Placebo - Trial 1

Group Type: PLACEBO_COMPARATOR

Placebo

Intervention Type: DIETARY_SUPPLEMENT

Acute placebo intake (3 mg/kg of maltodextrin)

Placebo - Trial 2

Group Type: PLACEBO_COMPARATOR

Placebo

Intervention Type: DIETARY_SUPPLEMENT

Acute placebo intake (3 mg/kg of maltodextrin)

Interventions

Caffeine

acute caffeine intake (3 mg/kg)

Intervention Type: DIETARY_SUPPLEMENT

Placebo

Acute placebo intake (3 mg/kg of maltodextrin)

Intervention Type: DIETARY_SUPPLEMENT

Eligibility Criteria

Inclusion Criteria

• Age between ≥ 18 and ≤ 35 years.
• Body Mass Index (BMI) < 25 kg/m².
• Resistance-trained individuals (> 2 years of structured trained).
• Healthy men and women without neurological, cardiometabolic, immunological, or physical conditions that prevent them from exercising.
• Participants must be able to perform the tests described in the following section.

Exclusion Criteria

• History of neuromuscular diseases, heart diseases, or diseases that may affect liver or muscle metabolism.
• Use of drugs, other stimulants or sport supplements that interfere with the the study dietary supplement.
• Sedentary habits (<150 min/week of moderate exercise).
• Having undergone prolonged periods of forced physical inactivity during the 6 months prior to the study.
• Performing strenuous exercise during the 48 hours prior to the tests.
• Failure to replicate the same food intake on the two days of the experiments.
• Consuming caffeine or any other stimulant after 6 pm the day before the training or tests, to avoid headaches, discomfort, or lethargy among regular caffeine consumers.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 35 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Alcala

OTHER

Sponsor Role: lead

Responsible Party

Alberto Pérez-López

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Facultad de Medicina y Ciencias de la Salud. Universidad de Alcalá

Alcalá de Henares, Madrid, Spain

Countries

Spain

Other Identifiers

CEID/2024/2/039

Identifier Type: -

Identifier Source: org_study_id