Effects of Caffeine on Methacholine Challenge and Exhaled Nitric Oxide Levels.

NCT ID: NCT01057875

Last Updated: 2010-10-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-01-31

Study Completion Date

2010-02-28

Brief Summary

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To investigate whether or not the ingestion of caffeine with alter airway responsiveness to methacholine and/or change the level of exhaled nitric oxide.

Detailed Description

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Conditions

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Asthma

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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coffee with caffeine

Group Type EXPERIMENTAL

caffeine

Intervention Type OTHER

Starbuck's Grande Pike Roast coffee

decaffeinated coffee

Starbuck's Grande Pike Roast Decaf

Group Type PLACEBO_COMPARATOR

No caffeine

Intervention Type OTHER

Starbuck's Grande Pike Roast Decaffeinated Coffee

Interventions

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caffeine

Starbuck's Grande Pike Roast coffee

Intervention Type OTHER

No caffeine

Starbuck's Grande Pike Roast Decaffeinated Coffee

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* clinical diagnosis of asthma
* FEV1 greater than 65%

Exclusion Criteria

* asthma is poorly controlled
* presence of other airway disease (e.g. COPD)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Saskatchewan

OTHER

Sponsor Role lead

Responsible Party

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University of Saskatchewan

Principal Investigators

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Donald W Cockcroft, MD

Role: PRINCIPAL_INVESTIGATOR

University of Saskatchewan

Locations

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University of Saskatchewan

Saskatoon, Saskatchewan, Canada

Site Status

Countries

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Canada

References

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Yurach MT, Davis BE, Cockcroft DW. The effect of caffeinated coffee on airway response to methacholine and exhaled nitric oxide. Respir Med. 2011 Nov;105(11):1606-10. doi: 10.1016/j.rmed.2011.06.006. Epub 2011 Jul 2.

Reference Type DERIVED
PMID: 21726992 (View on PubMed)

Other Identifiers

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BIO REB 09-186

Identifier Type: -

Identifier Source: org_study_id