Comparison of Pesticide and Pharmaceutical Contaminants Levels in Placenta and Cord Blood Samples of Pregnant Women With Fetal Growth Retardation and Healthy Pregnant Women

NCT ID: NCT05088148

Last Updated: 2022-04-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-03-29

Study Completion Date

2023-03-26

Brief Summary

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Aim: In this study, pesticide and pharmaceutical contaminants levels in the placenta and cord blood of pregnant women with fetal growth retardation and healthy pregnant women will be compared in placenta and cord blood samples after delivery.

Detailed Description

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The study will be conducted with a total of 40 pregnant women, 20 of whom are in the control groups and those with FGR diagnoses. Cases in both groups will be matched in terms of demographic information. Demographic information (including socioeconomic status, educational level, region of residence), ultrasound and Doppler examination results, newborn weight at birth, APGAR score, gender, mode of delivery, whether there is a need for neonatal intensive care or not will be recorded.

Conditions

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Fetal Growth Retardation

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Group 1: FGR group

Estimated fetal weight \<10th percentile

. Pesticide and Pharmaceutical analysis

Intervention Type OTHER

Pesticide and Pharmaceutical analysis will be done with LC-MS/MS device.

Group 2: Control group

Healthy pregnants who will give birth 37th and after gestational week

. Pesticide and Pharmaceutical analysis

Intervention Type OTHER

Pesticide and Pharmaceutical analysis will be done with LC-MS/MS device.

Interventions

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. Pesticide and Pharmaceutical analysis

Pesticide and Pharmaceutical analysis will be done with LC-MS/MS device.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Between the ages of 18-40 years
* Gestational age between 320/7 - 396/7 weeks
* Singleton pregnancy
* For the FGR group: estimated fetal weight \<10th percentile
* For the control group: being healthy pregnant
* Intact amniotic membrane

Exclusion Criteria

* Multiple pregnancies
* Cardiovascular disease
* Chronic hypertension
* Autoimmune disease
* Intrahepatic cholestasis of pregnancy
* Preeclampsia-eclampsia
* Sepsis
* Placenta accreta spectrum
* Abnormalities of placenta
* The chromosomal or congenital structural anomaly of the fetus
* Smoking
* BMI \>30 kg/m2
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Kutahya Health Sciences University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Other Identifiers

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Kutahya Health Sciences Uni

Identifier Type: -

Identifier Source: org_study_id

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