The Relationship of Phthalate Exposure During Pregnancy and Preeclampsia

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-01-01

Study Completion Date

2022-10-31

Brief Summary

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Phthalates are a group of ubiquitous synthetic endocrine-disrupting chemicals. Fetal and neonatal periods are particularly susceptible to endocrine disorders, which prenatal exposure to phthalates causes. There is increasing evidence concerning the potential endocrine disrupting for phthalate exposure during pregnancy. Prenatal exposure phthalates would disrupt the level of sex hormone in pregnant women, which results in preeclampsia. The relationship of prenatal phthalate exposure with maternal and neonatal outcomes in human beings was often sex-specific associations. Because of the potentially harmful influence of prenatal phthalate exposure, steps should be taken to prevent or reduce phthalate exposure during pregnancy.

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Detailed Description

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Conditions

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Phthalate Exposure Preeclampsia Estrogen Progestin

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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healthy pregnant woman

pregnant woman without any disease of pregnancy

test Phthalates, estrogen and progesterone

Intervention Type OTHER

test mothers Phthalates in their urine, and test estrogen and progesterone receptor in placental tissue

pregnant woman with preeclampia

pregnant woman with preeclampia but without any other disease of pregnancy

test Phthalates, estrogen and progesterone

Intervention Type OTHER

test mothers Phthalates in their urine, and test estrogen and progesterone receptor in placental tissue

Interventions

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test Phthalates, estrogen and progesterone

test mothers Phthalates in their urine, and test estrogen and progesterone receptor in placental tissue

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Singleton pregnancy
* Term pregnancy with the gestational age of 37-40 weeks

Exclusion Criteria

* Maternal systemic diseases (hypertension disorders, immunological diseases) or pregnant complications (polyhydramnios, oligohydramnios, diabetes mellitus, intrahepatic cholestasis of pregnancy)
* Delivery before 37 weeks or after 40 weeks

Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes