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Dietry Pattern and Lead Levels in Pregnancy

NCT ID: NCT03408275

Last Updated: 2018-01-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

2167 participants

Study Classification

OBSERVATIONAL

Study Start Date

1991-04-01

Study Completion Date

1992-12-01

Brief Summary

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During pregnancy lead crosses the placenta freely and can have adverse effects on the fetus, with the potential for life-long impact on the child. Identification of dietary patterns and food groups in pregnancy in relation to measures of lead status could provide a more useful alternative to a nutrient-specific advice to minimise fetal exposure to lead during pregnancy. The aim is to evaluate whether dietary patterns and food groups are associated with blood lead concentrations in pregnancy.

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Detailed Description

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Whole blood samples were collected from pregnant women enrolled in the Avon Longitudinal Study of Parents and Children observational birth cohort study and were analysed for lead. Dietary pattern scores were derived from principal components analysis of a food frequency questionnaire. Associations of quartiles of dietary pattern scores, and of food groups categorised by frequency of consumption, with the likelihood of blood lead concentration (B-Pb) ≥5 µg/dl will be identified with adjusted logistic regression (n=2167).

Conditions

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Dietary Habits Lead Poisoning Pregnancy Related

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Pregnant women

Pregnant women enrolled in ALSPAC

None - observational

Intervention Type OTHER

None - observational

Interventions

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None - observational

None - observational

Intervention Type OTHER

Eligibility Criteria

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Exclusion Criteria

\-
Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Wellcome Trust

OTHER

Sponsor Role collaborator

Medical Research Council

OTHER_GOV

Sponsor Role collaborator

Bristol Biomedical Research Unit

UNKNOWN

Sponsor Role collaborator

University of Bristol

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Nic Timpson, PhD

Role: STUDY_DIRECTOR

University of Bristol

Study Documents

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Document Type: Individual Participant Data Set

ALSPAC data available to researchers on application through the website

View Document

Other Identifiers

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ALSPAC_2

Identifier Type: -

Identifier Source: org_study_id

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