Catestatin and Hypertension in Pregnancy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

400 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-05-14

Study Completion Date

2017-12-31

Brief Summary

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Catestatin is a kind of protein involved with cardiovascular disease. Accumulated evidence shows that Catestatin may be a predictor of primary hypertension, but whether it plays the same role in pregnant hypertensive disorders needs to be determined. By measuring the plasma level of Catestatin, main biochemical marks and UCG in healthy pregnancy and pregnancy with hypertension, the research may contribute to this problem.

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Detailed Description

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Conditions

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Pre-Eclampsia Eclampsia Hypertension, Pregnancy-Induced Hypertension in Pregnancy

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Hpertension

No interventions assigned to this group

Health

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Healthy pregnancy women
* Pregnancy women with hypertension

1. Despite the pregnant gestational age , systolic blood pressure ≥140 mm Hg OR a diastolic blood pressure of ≥90 mm Hg measured three times more than 24 hours apart
2. Pregnant gestational age \> 20 weeks, systolic blood pressure ≥140 mm Hg OR a diastolic blood pressure of ≥90 mm Hg measured twice more than 4 hours apart

Exclusion Criteria

* Lack of blood sample at the specified enrollment period
* Women who refuse the study
* Other illness which needs medications interfering with blood pressure (eg: Asthma requiring systemic steroids)
* Known coronary artery disease or heart failure
* Serious medical illness (eg: renal insufficiency, congestive heart disease, chronic respiratory insufficiency, uncontrolled infection).
* multiple endocrine neoplasia or Cushing's syndrome or mixed tumours or pheochromocytoma or medullary thyroid carcinoma.
* previous history of malignant tumour, with the exception of carcinoma in situ of the uterine cervix or non-melanoma skin cancer
* renal insufficiency

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes