Effects of Mango Intake on Skin Health and Gut Microbiome Changes in Postmenopausal Women

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

70 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-05-30

Study Completion Date

2023-06-30

Brief Summary

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Mangos are a rich source of nutrients such as carotenoids, vitamin C and fiber, as well as polyphenols and phenolic acids such as mangiferin, ellagic acid, and gallotannins. Mango extract has been reported to protect against photo-aging of the skin in an animal model exposed to UVB radiation, reducing the length of wrinkles and increasing collagen bundles. Beta-carotene and other carotenoids are known to provide skin protection from sunlight, but other compounds in mangos, may also be important in reducing oxidative damage in aging skin.

We have recently completed a pilot study showing a clear trend in skin wrinkle reduction when postmenopausal women consumed 85g of Ataulfo mangos, four times per week for 16 weeks. To confirm and extend these results, a larger study is proposed.

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Detailed Description

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Conditions

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Photoaging

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Healthy postmenopausal women aged 50 - 70, Fitzpatrick skin type I, II, or III

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Mango

85g mango, 4x/week

Group Type EXPERIMENTAL

Food

Intervention Type OTHER

85g mango, 4x/week

No Mango

No mango intake

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Food

85g mango, 4x/week

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* 50 - 70 years old
* Postmenopausal
* Fitzpatrick skin type I, II, or III
* BMI 18.5 - 35
* Must be willing to comply with all protocol requirements
* Must be willing to have flash photo facial images taken with the imaging systems