Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
2000 participants
INTERVENTIONAL
2021-05-05
2022-07-31
Brief Summary
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Detailed Description
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Our aim is to improve our understanding of the prevalence and symptoms of RED-S in international and Canadian athletes and para-athletes, along with developing screening tools and treatment protocols to manage RED-S in order to improve athlete health, availability and performance.
Objectives:
1. Assess the prevalence of self-reported RED-S health outcomes in international and Canadian elite female and male athletes and para-athletes as well as recreational athletes (Study A);
2. Assess the prevalence and severity of measured standard/basic RED-S health outcomes including biomarkers and potential longitudinal (6-mo) tracking of outcomes across the Canadian Olympic and Paralympic Sport Institute Network (COPSI) (Study B);
3. Implement a more advanced assessment, using novel RED-S assessment parameters in a smaller cohort of key athletes, including potential longitudinal tracking over a 6-mo period (Study C);
4. Assess longitudinal changes and the treatment of RED-S symptoms across a 6-month follow-up period in a small cohort of elite Canadian athletes willing to partake in an 'holistic' RED-S treatment intervention arm (Study D);
5. Utilize the data created from Studies A,B,C,and D to develop and validate potentially novel RED-S assessment parameters in order to further validate the 'new' IOC RED-S clinical assessment tool (CAT) version 2 to aid in the diagnosis of RED-S.
Justification:
This study will be the first to systematically assess the prevalence and severity of outcomes of RED-S in a large group of international and Canadian athletes and para-athletes (A), and within the COPSI network (B,C), utilising physiological and performance tests and training metrics for a more holistic assessment of potential outcomes (B,C,). This study will also aim to strengthen the literature regarding to the time-course of changes in these outcomes (B,C,D) and the efficacy of a simple nutritional intervention arm on these changes (D). Finally, this multicentre project will be the largest to date in Canada and globally, and the first to produce data on the prevalence of RED-S within the COPSI network (across A,B,C,D).
Research Design:
This is an observational study including online survey and physiological testing with potential for follow-up in a subset of athletes. A separate study arm (study D) will be an intervention arm with follow-up.
Statistical analysis:
Analysis will be a combination of basic statistics such as t-tests and ANOVA's, as well as more advanced statistical modelling (e.g. stepwise regression modelling, with first identifying collinearity among independent variables via the implementation of variance inflation factors (VIFs)) as well as questionnaire-based statistics and potentially principal components analysis (PCA) will be implemented.
Physiological data will be plotted against survey data to create links between RED-S symptoms among various athlete groups (female vs male, able bodied vs disabled, sports groups, age categories, etc.)
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
SCREENING
NONE
Study Groups
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Global screening of high-performance athletes for REDS
This arm collects data with an online survey to assess prevalence and signs and symptoms of REDS in elite female and male elite and recreational athletes and para-athletes over the age of 15 years across the world.
No interventions assigned to this group
Basic screening of Canadian high-performance athletes for REDS
In this study arm, varsity level to elite Canadian athletes and para-athletes will complete a baseline blood sample and potentially (where abnormalities are present) a follow-up 6 months later.
No interventions assigned to this group
Advanced screening of Canadian high-performance athletes for REDS
In this study arm, varsity level to elite Canadian athletes and para-athletes will complete a baseline test for bone density (DXA scans), resting metabolic rate and exercise testing. Potentially (where abnormalities are present) a follow-up 6 months later.
No interventions assigned to this group
Treatment of Canadian athletes with REDS: a holistic intervention arm
In this arm, varsity level to elite Canadian athletes and para-athletes with REDS will participate in a nutritional intervention aiming to improve energy availability and thus, REDS status.
Treatment of REDS using a holistic treatment arm
This arm aims to treat athletes with REDS symptoms by implementing a holistic, individualized nutrition intervention to improve energy availability and thus restore impaired body function due to REDS.
Interventions
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Treatment of REDS using a holistic treatment arm
This arm aims to treat athletes with REDS symptoms by implementing a holistic, individualized nutrition intervention to improve energy availability and thus restore impaired body function due to REDS.
Eligibility Criteria
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Inclusion Criteria
* Female or male athlete or para-athlete currently and actively training for and racing in an Olympic sports event
* Age \>15 years
Exclusion Criteria
* Pregnant
15 Years
ALL
Yes
Sponsors
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Mitacs
INDUSTRY
University of British Columbia
OTHER
Trent Stellingwerff
OTHER
Responsible Party
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Trent Stellingwerff
Director of Performance Solutions, Innovation & Research for Canadian Sport Institute Pacific (CSI Pacific) Adjunct Faculty - Exercise Science, Physical & Health Education (EPHE), University of Victoria (UVic)
Principal Investigators
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Trent Stellingwerff, Ph.D.
Role: PRINCIPAL_INVESTIGATOR
Canadian Sport Institute Pacific, University of Victoria, University of British Columbia
Locations
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University of Victoria
Victoria, British Columbia, Canada
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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RED-S multicenter 2020-22
Identifier Type: -
Identifier Source: org_study_id
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