Exercise in Hypoxia and Nitrate Supplementation in Athletes: is the Whole Greater Than the Sum of Its Parts?

NCT ID: NCT06727656

Last Updated: 2024-12-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-02-01

Study Completion Date

2020-07-22

Brief Summary

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Determine the combined effect of training in hypoxia and nitrate supplementation on the performance and health of athletes at sea-level and altitude conditions.

Detailed Description

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Determine the combined effect of training in hypoxia and nitrate supplementation on the performance and health of athletes at sea-level and altitude conditions. It is hypothesized that the combined effect of these interventions will promote an additional performance and health improvement in this population at sea-level and altitude conditions, compared with the single effect.

Conditions

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Hypoxia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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HNO: High intensity interval training (HIIT) + nitrate supllementation (NO3-).

Performed 12 high-intensity interval-training (HIIT) sessions during a 4-week period (3 sessions/ week) under normobaric hypoxia conditions (FiO2=\~13%, \~3000 m) with NO3- supplement.

Group Type EXPERIMENTAL

Nitrate + Hypoxia

Intervention Type COMBINATION_PRODUCT

The combined effect of nitrate supplementation and hypoxia training on both performance and health at sea-level and altitude conditions.

HPL: High intensity interval training (HIIT) + placebo supllementation.

Performed 12 high-intensity interval-training (HIIT) sessions during a 4-week period (3 sessions/ week) under normobaric hypoxia conditions (FiO2=\~13%, \~3000 m) with placebo supplement.

Group Type ACTIVE_COMPARATOR

Placebo + Hypoxia

Intervention Type DIETARY_SUPPLEMENT

The combined effect of placebo supplementation and hypoxia training on both performance and health at sea-level and altitude conditions.

CON: High intensity interval training (HIIT) + placebo supllementation.

Performed 12 high-intensity interval-training (HIIT) sessions during a 4-week period (3 sessions/ week) under normoxic conditions (FiO2=\~20.9%) with placebo supplement.

Group Type PLACEBO_COMPARATOR

Control

Intervention Type OTHER

The combined effect of placebo supplementation and normoxia training on both performance and health at sea-level and altitude conditions.

Interventions

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Nitrate + Hypoxia

The combined effect of nitrate supplementation and hypoxia training on both performance and health at sea-level and altitude conditions.

Intervention Type COMBINATION_PRODUCT

Placebo + Hypoxia

The combined effect of placebo supplementation and hypoxia training on both performance and health at sea-level and altitude conditions.

Intervention Type DIETARY_SUPPLEMENT

Control

The combined effect of placebo supplementation and normoxia training on both performance and health at sea-level and altitude conditions.

Intervention Type OTHER

Other Intervention Names

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Beetroot Juice + Atitude training Placebo Juice + Atitude training Placebo Juice + Normoxia training

Eligibility Criteria

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Inclusion Criteria

* trained male subjects, regularly involved in competitive running, cycling and/ or triathlon events (4-5 times per week) in the past five years

Exclusion Criteria

* smoking or other chronic issues
* using medication or dietary supplements in the last 3 months, or during the duration of the study
* being exposed to altitude (≥2000 m) in the last 3 months
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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University of Trás-os-Montes and Alto Douro

OTHER

Sponsor Role lead

Responsible Party

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Ana Sousa

PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Ana Sousa, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Maia

Locations

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University of Trás-os-Montes e Alto-Douro

Vila Real, , Portugal

Site Status

Countries

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Portugal

Other Identifiers

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Hypoxia

Identifier Type: -

Identifier Source: org_study_id