Changes in the Hormonal and Inflammatory Profile of Young Sprint- and Endurance-trained Athletes.

NCT ID: NCT06150105

Last Updated: 2023-12-06

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 24 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2018-02-16
• Study Completion Date: 2018-12-10

Brief Summary

One essential element of athlete training is conditioning camps, where athletes undergo a rigorous and targeted training schedule to prepare for upcoming sporting events. During sports camps, due to the accumulation of a large number of training units, including high-intensity exercises, athletes react with post-exercise overload, acute fatigue, and overreaching which can become a chronic overtraining syndrome. Overtraining syndrome is a very specific and severe condition where overtraining without adequate rest and recovery leads to performance decrements lasting more than 2-3 months, coupled with a mood disturbance. The exact etiology and pathogenesis are unknown and actively being investigated.

During training camps the balance between training volumes and recovery is often a delicate one and, the accumulation of exercise-induced stress may exceed the capacity of both neuroendocrine and immune adaptation leading to an alteration of physiological functions, decreasing adaptation to performance, impairment of psychological processing, immunological dysfunction, and biochemical abnormalities. Moreover, there is currently a lack of biomarkers accessible to assist in diagnosing and, what's even more important - help to prevent the overtraining syndrome, except for the continued presence of unexplained underperformance despite athletes' adequate rest and recovery.

Thus, this study aims to explain how long and intensive training for endurance affects the hormonal and immune systems of young athletes.

The main questions it aims to answer are:

1. How does intense training influence hormonal and immune responses in young, trained athletes?

2. Does training specialization affect the hormonal and immune response to intense training?

Detailed Description

Twenty-four young male and female athletes, specializing in athletics disciplines such as sprint (hurdles, 100m, 110m), and endurance: race walk, 5000m, and 10000m, volunteered to take part in this study. Investigation was held during 9 days of the training camp (preparatory period, general preparation sub-period), which was aimed at increasing the endurance and flexibility of athletes. During the training camp, all subjects occupied the same accommodations and followed the same training plan and diet schedules. The camp regime included 2 training sessions per day, lasting 4 hours per day, and a total of 21 hours per 9 days. Blood samples were taken always in the same conditions, from the antecubital veins. Participants were seated in a recumbent position for a minimum of 10 minutes before blood draws to stabilize the hydrostatic condition. Before collection of the first sample (rested baseline), participants were asked to avoid any intense exercise at least 24 hours before sampling. Next samples were taken after 4 days and after another 5 days of training camp (in total after 9 days). The concentration of catecholamines: epinephrine and norepinephrine in serum was measured as well and the responsiveness of the adrenal medulla to the sympathetic nervous activity was estimated by the ratio E/NE calculated. Also, concentrations of cortisol, hs-CRP, and myoglobin were measured and changes in blood morphology were estimated.

Conditions

Overtraining Syndrome

Keywords

epinephrine, norepinephrine, cortisol, athletes, fatigue

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

sprint-trained

Sprint-trained athletes: 6 male and 6 female, aged average 15 y.,

Exercise training

Intervention Type: OTHER

Intense endurance training

endurance-trained

Endurance-trained athletes: 6 male and 6 female, aged average 15 y.,

Exercise training

Intervention Type: OTHER

Intense endurance training

Interventions

Exercise training

Intense endurance training

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• age 15-17 years,
• minimum of 3 years of training experience,
• specialization in anaerobic and aerobic disciplines.

Exclusion Criteria

• presence of acute or chronic inflammation
• fever, infections, injuries
• se of any anti-inflammatory drugs.

• Minimum Eligible Age: 15 Years
• Maximum Eligible Age: 17 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Poznan University of Physical Education

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Joanna Ostapiuk-Karolczuk, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Poznan University of Physical Education

Locations

Poznań University of Physical Education

Poznan, , Poland

Countries

Poland

References

Ostapiuk-Karolczuk J, Kasperska A, Dziewiecka H, Cieslicka M, Zawadka-Kunikowska M, Zaleska-Posmyk I. Changes in the hormonal and inflammatory profile of young sprint- and endurance-trained athletes following a sports camp: a nonrandomized pretest-posttest study. BMC Sports Sci Med Rehabil. 2024 Jun 20;16(1):136. doi: 10.1186/s13102-024-00924-3.

Reference Type: DERIVED

PMID: 38898468 (View on PubMed)

Other Identifiers

530/18

Identifier Type: -

Identifier Source: org_study_id