NHF vs. COT in Hypoxemic Pandemic Viral Illness

NCT ID: NCT04750408

Last Updated: 2022-03-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

52 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-01-22

Study Completion Date

2022-06-22

Brief Summary

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The study compares oxygen and NHF in patients with acute viral illness. The duration will be 72h. After them physiological parameters and the outcome will be evaluated.

Detailed Description

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Conditions

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Acute Viral Bronchitis Hypoxemic Respiratory Failure Hypercapnic Respiratory Failure

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Oxygen use

Patients will use standard oxygen via face mask of nasal prongs as usual care.

Group Type ACTIVE_COMPARATOR

Standard oxygen

Intervention Type DEVICE

COT describes the application of low-flow oxygen in any way (Hudson mask, nasal prongs,...).

NHF use

Patients will use NHF instead of oxygen. Oxygen will be supplemented via the NHF flow.

Group Type EXPERIMENTAL

Nasal high-flow

Intervention Type DEVICE

F is combination of room air supplemented with oxygen can be better patients. This gas mixture will be provided to the patient with a specialized nasal prong.

Interventions

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Standard oxygen

COT describes the application of low-flow oxygen in any way (Hudson mask, nasal prongs,...).

Intervention Type DEVICE

Nasal high-flow

F is combination of room air supplemented with oxygen can be better patients. This gas mixture will be provided to the patient with a specialized nasal prong.

Intervention Type DEVICE

Other Intervention Names

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COT NHF

Eligibility Criteria

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Inclusion Criteria

* acute hyperemic viral illness
* acute hyperemic or hypercapnia respiratory failure

Exclusion Criteria

* intubation criteria
* indication for NIV therapy
* influences of primary endpoint (rip fracture, lung embolism)
* tracheostomy
* other interventional trials
* noncompliance
Minimum Eligible Age

18 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Jens Bräunlich

OTHER

Sponsor Role lead

Responsible Party

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Jens Bräunlich

Chair Pneumology and Respiratory Medicine

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Jens Bräunlich, MD

Role: STUDY_CHAIR

chair

Locations

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Klinikum Emden

Emden, , Germany

Site Status RECRUITING

Countries

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Germany

Central Contacts

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Jens Bräunlich, MD

Role: CONTACT

+494921981598

Facility Contacts

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Jens Bräunlich, MD

Role: primary

+494921981598

Other Identifiers

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01

Identifier Type: -

Identifier Source: org_study_id

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