Analysis of BPA Concentration in Serum in Women of Reproductive Age With Autoimmune Thyroid Disease

NCT ID: NCT04682340

Last Updated: 2022-01-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

80 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-12-22

Study Completion Date

2022-01-19

Brief Summary

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The aim of the study is to assess the relationship between the concentration of bisphenol A in serum and selected parameters of thyroid function in women of reproductive age with thyroid dysfunction - Hashimoto's disease and Graves' disease.

Detailed Description

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Conditions

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Hypothyroidism Hyperthyroidism Hashimoto Disease Graves Disease

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Hashimoto's Group

Thyroid antibody positive and hypothyroidism

Serum BPA

Intervention Type DIAGNOSTIC_TEST

Serum BPA levels will be compared between women with autoimmune thyroid disease and normal women.

Graves' Group

Thyroid antibody positive and hyperthyroidism

Serum BPA

Intervention Type DIAGNOSTIC_TEST

Serum BPA levels will be compared between women with autoimmune thyroid disease and normal women.

Control Group

Thyroid antibody negative and euthyroidism

Serum BPA

Intervention Type DIAGNOSTIC_TEST

Serum BPA levels will be compared between women with autoimmune thyroid disease and normal women.

Interventions

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Serum BPA

Serum BPA levels will be compared between women with autoimmune thyroid disease and normal women.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Graves' disease or Hashimoto's disease (positive thyroid autoantibody)
* Control group: thyroid autoantibody negative, normal thyroid function
* Women aged 18 to 45 in both the control group and experimental group

Exclusion Criteria

* Pregnancy and lactating women
* Previous or planned treatment with 131I or thyroidectomy
* The use of drugs affecting the thyroid function (lithium, amiodarone, interferon a, sodium nitroprusside, sunitinib, sorafenib, iodine contrast, antibiotics / antifungals / antivirals (for at least 4 weeks prior to recruitment to the study), which do not result from the treatment of thyroid disease (levothyroxine, thyreostatic drugs, glucocorticoids)
* Active malignancy
* Other autoimmune diseases
* Other endocrine diseases
* Patients with severe liver, kidney or heart failure
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Jagiellonian University

OTHER

Sponsor Role lead

Responsible Party

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Karolina Zawadzka

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Jagiellonian University Medical College

Krakow, Malopolska, Poland

Site Status

Countries

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Poland

Other Identifiers

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BPA-Thyroid

Identifier Type: -

Identifier Source: org_study_id

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