The Relationship Between Urine Iodine, Urine Bisphenol A and Autoimmune Thyroid Disease in Reproductive Women

NCT ID: NCT03932487

Last Updated: 2020-03-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

142 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-06-24

Study Completion Date

2022-10-01

Brief Summary

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Autoimmune thyroid disease (AITD) is the main cause of hypothyroidism in reproduction women, iodine and bisphenol A are the environmental factors for AITD. The research was mainly designed to investigate the effect of iodine and BPA on AITD in reproduction women to provide new evidence for hypothyroidism in reproduction women.

Detailed Description

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71 patients with thyroid autoantibody positive were treated as AITD group, another 71 healthy reproduction women were selected as normal group. Women age, BMI, thyroid disease history, family history, marital and reproductive history, whether the application of iodized salt, thyroid function and thyroid autoantibodies detection were recorded. Meanwhile urine iodine, urinary iodine/urinary creatinine, urine BPA and urinary BPA/creatinine were tested. The urine iodine and BPA levels of the two groups were compared. Taking AITD as the dependent variable, logistic regression was conducted to analyze whether urinary iodine and BPA were risk factors of AITD.

Conditions

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The Effect of Iodine and BPA on AITD in Reproduction Women

Study Design

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Observational Model Type

OTHER

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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AITD group

Thyroid antibody positive and hypothyroidism

urinary iodine and urine BPA

Intervention Type OTHER

urinary iodine and urine BPA

normal group

Thyroid antibody negative and hypothyroidism

urinary iodine and urine BPA

Intervention Type OTHER

urinary iodine and urine BPA

Interventions

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urinary iodine and urine BPA

urinary iodine and urine BPA

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. AITD group: positive thyroid autoantibody (one thyroid autoantibody), normal thyroid function.
2. Normal group: thyroid autoantibody negative, normal thyroid function.
3. No previous history of hyperthyroidism or hypothyroidism, no history of thyroid surgery or I131 radiotherapy, and no thyroid hormone or anti-thyroid drugs were used.

Exclusion Criteria

1. Patients with severe liver, kidney, heart and other important organ failure.
2. Merger with other autoimmune diseases.
3. Amiodarone, iodine contrast agent and other drugs affecting thyroid function are used.
Minimum Eligible Age

20 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Xiaomei Zhang

OTHER

Sponsor Role lead

Responsible Party

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Xiaomei Zhang

Director, Head of endocrinology department.

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Peking University international hospital

Beijing, Beijing Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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jun zhao

Role: CONTACT

+8601069007608

Facility Contacts

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jun zhao

Role: primary

+8601069006708

Other Identifiers

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Peking UIH

Identifier Type: -

Identifier Source: org_study_id

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