Thyroid Function Tests and Status of Thyroid Autoantibodies in Covid-19 Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-09-01

Study Completion Date

2020-12-07

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

COVID-19 infection causes a hypersensitive immune reaction and widespread inflammation through cytokines in various organs of the body, especially the lungs.

This cytokine-mediated widespread inflammation can also affect the thyroid gland, causing thyroiditis and impaired thyroid functions.

The researchers evaluated thyroid function tests and thyroid autoantibodies in patients hospitalized for COVID-19 infection. Researchers excluded patients on intensive care therapy and patients with known thyroid disease.

The researchers examined the relationship of thyroid hormones and thyroid autoantibodies to COVID-19 disease, white blood cells, neutrophil / lymphocyte ratio, c reactive protein, fibrinogen, procalcitonin, ferritin, and D-dimer stages in these patients. Researchers compared changes in thyroid hormones and autoantibodies in people without COVID-19 infection and without thyroid disease.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Vitamin D, Hashimato's Thyroiditis and Thyroid Functions

NCT06726967

Vitamin D Thyroid Autoimmune Disease

COMPLETED

The Status of Parathyroid Hormone Secretion in Covid-19 Patients

NCT04662437

COVID-19 Infection Parathyroid Gland Parathyroid Hormone +3 more

COMPLETED

Evaluation of Thyroid Function in Patients With Chronic Kidney Disease

NCT04658524

Chronic Kidney Disease Thyroid Dysfunction

ACTIVE_NOT_RECRUITING

Physiopathology and Sequelae of COVID-19 Infection

NCT04563676

Covid19 TSH Cortisol

ACTIVE_NOT_RECRUITING NA

Preoperative Hemogram Parameters and BRAF Molecular Test Detected by Bethesda 3 Cytology.

NCT06539702

Blood Platelet Disorder BRAF V600E Thyroid Nodule +1 more

RECRUITING

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The coronavirus-2 (SARS-COV-2) virus, which can cause severe acute respiratory syndrome through droplet, has caused the global Coronavirus 19 (COVID-19) pandemic. COVID-19 infection can be asymptomatic as well as lead to severe illness and even death. This virus causes a hypersensitive immune reaction and varying degrees of widespread inflammation through cytokines in various organs of the body, mainly the lungs.

Cytokine-mediated widespread inflammation caused by the virus may also affect the thyroid gland and thyrocytes, causing thyroiditis and impairment of thyroid functions. Thus, it may cause changes in thyroid hormones and thyroid autoantibodies.

In study, the researchers found that in patients who were symptomatic with COVID-19 infection and who were hospitalized, thyroid function tests such as serum thyrotropin (TSH), free triiodothyronine (FT3), free thyroxine (FT4) and thyroid peroxidase antibodies (TPOAb), anti-thyroglobulin evaluated antibodies (TGAb). The investigators did not recruit patients in intensive care and patients with known thyroid disease.

Researchers looked at the association of patients' thyroid hormones and thyroid autoantibodies with white blood cells, neutrophil / lymphocyte ratio, c reactive protein, fibrinogen, procalcitonin, ferritin, D-dimer from hospital archives. The researchers determined how the thyroid hormones and autoantibodies of patients with COVID-19 infection were compared with healthy individuals without COVID-19 infection and thyroid disease.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

COVID-19 Infection Thyroid Function Tests Inflammation; Thyroid Inflammatory Markers

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Covid Disease Patient Group

Researchers evaluated serum thyrotropin, free triiodothyronine, free thyroxine hormones, thyroid peroxidase antibodies and anti-thyroglobulin antibodies in patients hospitalized for COVID-19 infection. The researchers evaluated the results of white blood cells, neutrophil / lymphocyte ratio, c reactive protein, fibrinogen, procalcitonin, ferritin, D-dimer in Covid-9 patients.

Venous blood was collected for biochemistry testing.

Intervention Type DIAGNOSTIC_TEST

For the measurement of blood tests, 10 ml of blood samples were taken from the right forearm veins with a syringe.

Covid-Free Control Group

Researchers evaluated the results of serum thyrotropin, free triiodothyronine, free thyroxine hormones, thyroid peroxidase antibodies and anti-thyroglobulin antibodies, white blood cells, neutrophil / lymphocyte ratio, c reactive protein, fibrinogen, procalcitonin, ferritin, D-dimer in the non-patient control group.

Venous blood was collected for biochemistry testing.

Intervention Type DIAGNOSTIC_TEST

For the measurement of blood tests, 10 ml of blood samples were taken from the right forearm veins with a syringe.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Venous blood was collected for biochemistry testing.

For the measurement of blood tests, 10 ml of blood samples were taken from the right forearm veins with a syringe.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* To accept research.
* Being over the age of 18.
* COVID 19 test results to be positive.
* Not taking thyroid disease medication before.
* Receiving inpatient treatment in the COVID service in the hospital.

Exclusion Criteria

* Not accepting research.
* Be under the age of 18.
* Negative COVID 19 test results for patients.
* COVID patients treated as outpatient.
* Thyroid disease in the healthy control group.

Minimum Eligible Age

18 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes