Association of TTGA (Tissue Transglutaminase Antibody) and Histopathologic Findings in Thyroidectomy Patients

NCT ID: NCT04974255

Last Updated: 2021-07-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

198 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-05-01

Study Completion Date

2021-07-30

Brief Summary

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Gluten sensitivity is the most common auto-immune disease associated with auto-immune thyroiditis. This association is through elevated anti-Tissue transglutaminase (Anti-tTG) levels both in Celiac disease and thyroiditis. In our study we tried to find if there is any correlation in between Anti-tTG and degree of fibrosis in thyroid tissue (Post-operative specimen).

Detailed Description

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Most common auto-immune disease associated with Celiac disease is autoimmune thyroiditis. This association in between Celiac disease and aout-immune thyroiditis is related with asymptomatic rise in anti-tTG levels. In our study, we planned to show that if there is any correlation of thyroiditis related fibrosis in thyroid tissue with anti-tTG IgA ( immune-globulin A) and IgG (immune-globulin G).

Conditions

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Thyroid Fibrosis

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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Operated Patients

Measurement of fibrosis degree and Anti-tTG levels

Group Type EXPERIMENTAL

Measuring of fibrosis in thyroid specimen and measuring of Anti-tTG in serum samples

Intervention Type OTHER

Examination of pathology specimen and laboratory measuring

Interventions

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Measuring of fibrosis in thyroid specimen and measuring of Anti-tTG in serum samples

Examination of pathology specimen and laboratory measuring

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Thyroiditis patients operated for any indication

Exclusion Criteria

* Patients with known IgA deficiency
Minimum Eligible Age

18 Years

Maximum Eligible Age

88 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Diskapi Yildirim Beyazit Education and Research Hospital

OTHER_GOV

Sponsor Role lead

Responsible Party

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Gorkem Gundogan

MD, Senior Resident of General Surgery

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Gorkem Gundogan

Role: PRINCIPAL_INVESTIGATOR

Not Affliated

Locations

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SBU Diskapi Yildirim Beyazit Training and Research Hospital

Ankara, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

Other Identifiers

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59/02

Identifier Type: -

Identifier Source: org_study_id

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