Role of Preoperative Serum Thyroglobulin Level to Differentiate Between Different Thyroid Nodules
NCT ID: NCT06157632
Last Updated: 2023-12-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
30 participants
INTERVENTIONAL
2023-12-20
2024-11-25
Brief Summary
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Detailed Description
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The gold standard of diagnosis for thyroid nodules is fine needle aspiration (FNA); however, fine needle aspiration cytology (FNAC) alone is insufficient to detect cancer because of inadequate cytology (5-15%) and in cases of follicular neoplasm (15-25%) where only surgery is diagnostically conclusive. Therefore, other factors in addition to FNA should be considered to predict malignancy. This study is done to evaluate the association between elevated pre-operative thyroglobulin levels and histopathologically proven thyroid carcinoma.
Metabolism of thyroglobulin occurs in the liver and via thyroid gland and recycling of the protein takes place. Circulating thyroglobulin features a half lifetime of 65 hours. Following thyroidectomy, it will take many weeks before thyroglobulin levels become undetectable. After thyroglobulin levels become undetectable (following thyroidectomy), levels are often serially monitored.
A subsequent elevation of the thyroglobulin level is an indicator of recurrence of papillary or follicular thyroid carcinoma. Hence, thyroglobulin levels in the blood are mainly used as a tumor marker for certain kinds of thyroid cancer (particularly papillary or follicular thyroid cancer). Thyroglobulin is not produced by medullary or anaplastic carcinoma.
Therefore, this study tries to evaluate the association between the preoperative thyroglobulin levels and thyroid carcinoma proven by post-operative histopathology.
Conditions
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Study Design
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NA
SINGLE_GROUP
DIAGNOSTIC
NONE
Study Groups
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Patients with thyoid nodules
Patients with thyroid nodules that will do thyroidectomy
Thyriodectomy
Thyroidectomy
Interventions
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Thyriodectomy
Thyroidectomy
Eligibility Criteria
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Inclusion Criteria
2. patients with solitary thyroid nodules
3. pateints who are fit for surgeries
Exclusion Criteria
2\_ age below 15 years and above 70 years old
3-patients with thyroid nodule receiving drugs that affect thyroglobulin level as iodine
15 Years
70 Years
ALL
No
Sponsors
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Assiut University
OTHER
Responsible Party
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Ahmed Gamal Hussein Hasan
Resident doctor at general surgery departement assiut university
Principal Investigators
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Mohamed Baker, Prof
Role: STUDY_DIRECTOR
Assiut University
Mahmoud Thabet, Assistant.prof
Role: STUDY_DIRECTOR
Assiut University
Central Contacts
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Other Identifiers
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Thyroglobulin level
Identifier Type: -
Identifier Source: org_study_id