In Vivo Glycocalyx as Predictor of Complications After Cardiac Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

600 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-11-30

Study Completion Date

2023-12-30

Brief Summary

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Cardiac surgery has been described as altering endothelium structure and function, notably because of the use of cardiac-pulmonary bypass (CPB). Among the endothelial structure, glycocalyx, the thin layer recovering the endothelial surface, may be altered by the inflammatory process and probably the modification of flow during CPB. Endothelial and glycocalyx integrity are essential for vascular function and glycocalyx destruction is associated with organ failure and mortality. On the other hand, a chronic alteration of glycocalyx is observed in many diseases such as diabetes, hypertension or chronic kidney failure, all pathologies frequently observed in patients benefiting grom cardiac surgery.

Thus the preoperative alteration of glycocalyx may be associated with postoperative organ failure.

Detailed Description

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Conditions

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Endothelial Dysfunction Cardiovascular Diseases Surgery

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* all patients benefiting from a cardiac surgery with cardio-pulmonary bypass

Exclusion Criteria

* impossibility to carry out the measurement by glycocheck device
* refusal to participate

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Responsibility Role SPONSOR

Locations

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Rouen University Hospital

Rouen, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Emmanuel Besnier, MD PhD

Role: CONTACT

Phone: +33232881705

Email: [email protected]

Facility Contacts

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emmanuel besnier, MD

Role: primary

Other Identifiers

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2020/202/OB

Identifier Type: -

Identifier Source: org_study_id