Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
31 participants
OBSERVATIONAL
2015-03-31
2015-06-30
Brief Summary
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The endothelium is a regulator of vascular homeostasis, vascular tone and structure and exerts anticoagulant, antiplatelet and fibrinolytic properties. Endothelial dysfunction is characterized by a decreased vascular bioavailability of nitric oxide probably due to an increased degradation of nitric oxide via its interaction with locally produced reactive oxygen species. No clinical studies have investigated whether peri- and postoperative endothelial dysfunction is associated with an increased risk of perioperative myocardial injury. Endothelial dysfunction may be a key element in the development of perioperative myocardial injury.
The aim of this observational clinical study is to closely examine the endothelial function and its dynamics in the early postoperative period.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Interventions
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Elective colon cancer surgery
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Previously included in the trial
* Surgery within 7 days of the trial
18 Years
100 Years
ALL
No
Sponsors
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Zealand University Hospital
OTHER
Responsible Party
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Sarah Victoria Ekeløf Busch
MD, Ph.d. student
Principal Investigators
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Sarah E Busch, MD
Role: PRINCIPAL_INVESTIGATOR
Department of Surgery, Koge University Hospital, Denmark
Locations
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Department of Surgery, Roskilde Hospital
Roskilde, , Denmark
Countries
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References
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Ekeloef S, Larsen MH, Schou-Pedersen AM, Lykkesfeldt J, Rosenberg J, Gogenur I. Endothelial dysfunction in the early postoperative period after major colon cancer surgery. Br J Anaesth. 2017 Feb;118(2):200-206. doi: 10.1093/bja/aew410.
Other Identifiers
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SBpoetry
Identifier Type: -
Identifier Source: org_study_id
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