Unraveling Perioperative Myocardial Injury

NCT ID: NCT06728111

Last Updated: 2024-12-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

1114 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-07-24

Study Completion Date

2027-03-01

Brief Summary

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The aim of this study is to gain insight into the etiology of myocardial injury after non cardiac surgery. Furthermore, suspected etiologies were explored and hierarchically classified into most likely cause how this determines prognosis and what factors are associated with improved outcome.

Detailed Description

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As above

Conditions

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Myocardial Injury Myocardial Injury After Non-Cardiac Surgery

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Interventions

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High sensitive Troponin T

The baseline population will consist of all patients who underwent a form of non-cardiac surgery. Baseline variables, medication use, type of surgery and perioperative hemodynamic and laboratory variables will be extracted from the hospital information system. One year mortality is registered, as well as major vascular events. This is in line with previous publications from our group. The adjudication strategy used for patients with myocardial injury. For the adjudication process minimal two senior anesthesiologists will be invited. Two members with at least one senior anesthesiologist will receive a sample of patients to adjudicate. Together the entire panel will adjudicate all patients. The goal to investigate the differences between the raters.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age \> 18 year of age
* Undergoing non-cardiac surgery in the Erasmus MC, with (high-sensitive) Troponin T \> 50 ng/L measured in any of the first three days after surgery.

Exclusion Criteria

* Re-operations within the study period.
* Daycare surgery
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Erasmus Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Felix van Lier

Anesthesiologist

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Sanne Hoeks, PhD

Role: STUDY_DIRECTOR

Epidemiologist

Felix van Lier, PhD

Role: PRINCIPAL_INVESTIGATOR

Anesthesiologist

Locations

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Erasmus Medical Center

Rotterdam, , Netherlands

Site Status

Countries

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Netherlands

Provided Documents

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Document Type: Study Protocol

View Document

Other Identifiers

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10945

Identifier Type: -

Identifier Source: org_study_id