Acute Lung Injury After Cardiac Surgery: Pathogenesis

NCT ID: NCT02475694

Last Updated: 2015-06-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-09-30

Study Completion Date

2009-03-31

Brief Summary

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The purpose of the present study is to visualize the inflammatory response and coagulation disorders during cardiac surgery in order to identify possible predictors for acute lung injury postoperatively.

Detailed Description

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Acute lung injury after cardiac surgery is a common complication. The pathophysiology is complex and still not fully elucidate. No specific biomarkers are identified and the diagnosis is solely based on impaired oxygenation.

The purpose of the present study is to identify biomarkers of inflammation and coagulation in blood withdrawn simultaneous from the pulmonary artery and the left atrium during surgery and up to 20 hours after weaning from cardiopulmonary bypass.

Conditions

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Acute Lung Injury Metabolic Disturbances Inflammation Coagulation; Intravascular Postoperative; Dysfunction Following Cardiac Surgery

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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No intervention

No treatment

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Elective surgery
* CABG
* In treatment with statins

Exclusion Criteria

* Acute surgery
* Valve replacement
* In treatment with immunodepressive drugs
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Aalborg University

OTHER

Sponsor Role collaborator

Aalborg University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Bodil Steen Rasmussen

Professor, PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Bodil S Rasmussen, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Aalborg University Hospital

Other Identifiers

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N-20080016

Identifier Type: -

Identifier Source: org_study_id

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