Post-Surgical Mediastinitis Within the CHU Brugmann Hospital

NCT ID: NCT03922191

Last Updated: 2019-07-16

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 19 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2019-02-12
• Study Completion Date: 2019-07-15

Brief Summary

Mediastinitis is an infectious complication that can occur after cardiac surgery. The incidence varies between 1 and 3% depending on the type of procedure and the patient's condition. The mortality of this severe postoperative complication rises from 10 to 35%, which makes it dreadful.

The major risk factors reported are obesity, diabetes, and immunosuppressive therapy. There are other less important ones: age, coronary bypass grafting (especially if using the two internal mammary arteries), nosocomial pneumonia, dialysis, prolonged mechanical ventilation, long operative asepsis, undrained retro-sternally hematoma, prolonged pre-operative hospitalization...).

Prevention is very important. The principle of asepsis must absolutely be respected. The use of prophylactic antibiotic therapy is recommended.

The most commonly encountered organisms are Staphylococcus aureus, coagulase-negative Staphylococci and gram-negative bacilli.

There are several treatment modalities that vary between centers and may be different depending on the surgical team's experience and the depth or extent of the infection. The common principles of these treatments are: antibiotic therapy and surgical debridement (the timing of which may vary). The timing and modalities of wound closure are subject to variations: immediate sternal closure with placement of multiple or delayed drains. Muscle flaps or large omentum transplant may be necessary if tissue loss is too important.

The investigators propose to review their experience in the treatment of cardiac post-surgery mediastinitis at Brugmann University Hospital in the last 20 years in both adult and pediatric patients.

Conditions

Mediastinitis

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

Pediatric population

Infants diagnosed with cardiac post-surgery mediastinitis within the HUDERF Hospital within the last 20 years.

Data extraction from medical files

Intervention Type: OTHER

Data extraction from medical files

Adult population

Adults diagnosed with cardiac post-surgery mediastinitis within the CHU Brugmann Hospital within the last 20 years.

Data extraction from medical files

Intervention Type: OTHER

Data extraction from medical files

Interventions

Data extraction from medical files

Data extraction from medical files

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• post-cardiac surgery mediastinitis
• patients of the CHU Brugmann (adults) and HUDERF (pediatric) Hospitals

Exclusion Criteria

• none

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Pierre Wauthy

OTHER

Sponsor Role: lead

Responsible Party

Pierre Wauthy

Medical Director of the Hospital

Responsibility Role: SPONSOR_INVESTIGATOR

Principal Investigators

Laura Pauels, MD

Role: PRINCIPAL_INVESTIGATOR

CHU Brugmann

Locations

CHU Brugmann

Brussels, , Belgium

Countries

Belgium

Other Identifiers

CHUB-Pauels

Identifier Type: -

Identifier Source: org_study_id