Contribution of L-Tyrosine to Human Decision Making in Stressful Situations
NCT ID: NCT04518254
Last Updated: 2022-11-25
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
17 participants
INTERVENTIONAL
2021-11-18
2022-04-07
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
1. Tyrosine treatment without stress exposure
2. Tyrosine treatment with stress exposure
3. Placebo treatment without stress exposure
4. Placebo treatment with stress exposure
Every participants will participate in the 4 arms in a random order.
PREVENTION
TRIPLE
Study Groups
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Tyrosine - Test
4 similar visits (day 0, day 3, day 6, day 9): Administration of L-tyrosine No stress exposure
Blood collection
A blood sample will be collected before and after treatment administration
L-Tyrosine 500 Mg
The participants will be administered 4 capsules of L-Tyrosine 500 mg per oral route
Cognitive tasks
The participants will perform cognitive decision-making tasks: Simon task and masking task after treatment administration
Anxiety scale
Spielberger's State Trait Anxiety Inventory (STAI) will be filled by the participants before and after cognitive tasks
Electromyography (EMG)
Electromyography measurements will be performed during cognitive tasks.
Electroencephalography (EEG)
Electroencephalography measurements will be performed during cognitive tasks.
Tyrosine - Stress
4 similar visits (day 0, day 3, day 6, day 9): Administration of L-tyrosine Stress exposure
Blood collection
A blood sample will be collected before and after treatment administration
L-Tyrosine 500 Mg
The participants will be administered 4 capsules of L-Tyrosine 500 mg per oral route
Cognitive tasks
The participants will perform cognitive decision-making tasks: Simon task and masking task after treatment administration
Stress exposure
Unpleasant but not painful skin stimulations will be administered to the participants at variable intervals on the left leg during the cognitive tasks
Anxiety scale
Spielberger's State Trait Anxiety Inventory (STAI) will be filled by the participants before and after cognitive tasks
Electromyography (EMG)
Electromyography measurements will be performed during cognitive tasks.
Electroencephalography (EEG)
Electroencephalography measurements will be performed during cognitive tasks.
Placebo - Test
4 similar visits (day 0, day 3, day 6, day 9): Administration of Placebo No stress exposure
Blood collection
A blood sample will be collected before and after treatment administration
Placebo
The participants will be administered 4 capsules of Lactose 500 mg (placebo) per oral route
Cognitive tasks
The participants will perform cognitive decision-making tasks: Simon task and masking task after treatment administration
Anxiety scale
Spielberger's State Trait Anxiety Inventory (STAI) will be filled by the participants before and after cognitive tasks
Electromyography (EMG)
Electromyography measurements will be performed during cognitive tasks.
Electroencephalography (EEG)
Electroencephalography measurements will be performed during cognitive tasks.
Placebo - Stress
4 similar visits (day 0, day 3, day 6, day 9): Administration of Placebo Stress exposure
Blood collection
A blood sample will be collected before and after treatment administration
Placebo
The participants will be administered 4 capsules of Lactose 500 mg (placebo) per oral route
Cognitive tasks
The participants will perform cognitive decision-making tasks: Simon task and masking task after treatment administration
Stress exposure
Unpleasant but not painful skin stimulations will be administered to the participants at variable intervals on the left leg during the cognitive tasks
Anxiety scale
Spielberger's State Trait Anxiety Inventory (STAI) will be filled by the participants before and after cognitive tasks
Electromyography (EMG)
Electromyography measurements will be performed during cognitive tasks.
Electroencephalography (EEG)
Electroencephalography measurements will be performed during cognitive tasks.
Interventions
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Blood collection
A blood sample will be collected before and after treatment administration
L-Tyrosine 500 Mg
The participants will be administered 4 capsules of L-Tyrosine 500 mg per oral route
Placebo
The participants will be administered 4 capsules of Lactose 500 mg (placebo) per oral route
Cognitive tasks
The participants will perform cognitive decision-making tasks: Simon task and masking task after treatment administration
Stress exposure
Unpleasant but not painful skin stimulations will be administered to the participants at variable intervals on the left leg during the cognitive tasks
Anxiety scale
Spielberger's State Trait Anxiety Inventory (STAI) will be filled by the participants before and after cognitive tasks
Electromyography (EMG)
Electromyography measurements will be performed during cognitive tasks.
Electroencephalography (EEG)
Electroencephalography measurements will be performed during cognitive tasks.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* History of neurological or psychiatric disorder
* History of nephrological or endocrine disorder or liver failure
* Hereditary tyrosinemia
18 Years
65 Years
ALL
Yes
Sponsors
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Direction Centrale du Service de Santé des Armées
OTHER
Responsible Party
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Locations
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Institut de Recherche Biomédicale des Armées
Brétigny-sur-Orge, , France
Countries
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Other Identifiers
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2019-A03194-53
Identifier Type: OTHER
Identifier Source: secondary_id
2018PPRC25
Identifier Type: -
Identifier Source: org_study_id
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