Influence of Breakfast Consumption on Chlorogenic Acid Metabolism in Humans

NCT ID: NCT01523028

Last Updated: 2013-06-05

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 14 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2011-09-30
• Study Completion Date: 2012-12-31

Brief Summary

Data and knowledge gathered on bioavailability of coffee phenolics is becoming more and more important, hence underlying the importance of better understanding the fate of these potential health promoting antioxidants. However, some analytical barriers as well as some key aspects of metabolism still remain to be fully elucidated to get the full picture of coffee metabolism and bioavailability. One aspect addressed in the present study is the impact of food matrix in modulating absorption, plasma appearance and urinary excretion of coffee bioactives.

Conditions

Healthy

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Coffee, bread and honey

200 mL coffee + 2 bread rolls + honey

Group Type: EXPERIMENTAL

Soluble Coffee

Intervention Type: OTHER

Amounts of chlorogenic acids will be normalized to body weight (3.1 mg CA / kg BW). Coffee will be reconstituted in 200 mL hot water and consumed 3 times in a row (min 1-week interval), alone or with a breakfast:

• 200 mL coffee or
• 200 mL coffee + 2 bread rolls + honey
• 200 mL coffee + 1 bread roll + peanut butter

Coffee, bread and peanut butter

200 mL coffee + 1 bread roll + peanut butter

Group Type: EXPERIMENTAL

Soluble Coffee

Intervention Type: OTHER

Amounts of chlorogenic acids will be normalized to body weight (3.1 mg CA / kg BW). Coffee will be reconstituted in 200 mL hot water and consumed 3 times in a row (min 1-week interval), alone or with a breakfast:

• 200 mL coffee or
• 200 mL coffee + 2 bread rolls + honey
• 200 mL coffee + 1 bread roll + peanut butter

200 mL black coffee

Group Type: EXPERIMENTAL

Soluble Coffee

Intervention Type: OTHER

Amounts of chlorogenic acids will be normalized to body weight (3.1 mg CA / kg BW). Coffee will be reconstituted in 200 mL hot water and consumed 3 times in a row (min 1-week interval), alone or with a breakfast:

• 200 mL coffee or
• 200 mL coffee + 2 bread rolls + honey
• 200 mL coffee + 1 bread roll + peanut butter

Interventions

Soluble Coffee

Amounts of chlorogenic acids will be normalized to body weight (3.1 mg CA / kg BW). Coffee will be reconstituted in 200 mL hot water and consumed 3 times in a row (min 1-week interval), alone or with a breakfast:

• 200 mL coffee or
• 200 mL coffee + 2 bread rolls + honey
• 200 mL coffee + 1 bread roll + peanut butter

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Healthy men and women
• Aged 20-44 years
• Caucasian origin
• Body mass index (BMI) 19-25 kg/m2
• Used to drinking coffee (similar to study coffee) on a daily basis
• Being able to tolerate a 48-hour coffee abstinence
• Normal oral glucose tolerance test
• Having signed the informed consent form

Exclusion Criteria

• Taking medication or dietary supplements
• Smoking
• Performing a competitive sport
• Having metabolic disorders
• Long gut transit time (>24 h)
• Blood donor
• Irregularity in menstrual cycle (for women)
• Pregnancy (for women)
• Subject who cannot be expected to comply with the study procedures.
• Currently participating or having participated in another clinical trial during the last 4 weeks prior to the beginning of this study.

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 44 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Société des Produits Nestlé (SPN)

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

University of Kaiserslautern

Kaiserslautern, , Germany

Countries

Germany

Other Identifiers

11.12.NRC

Identifier Type: -

Identifier Source: org_study_id