Dose Response Bioavailability of Coffee and Green Tea Antioxidants in Humans

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

23 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-09-30

Study Completion Date

2010-02-28

Brief Summary

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Coffee and green tea are 2 widely consumed beverages. Both contain polyphenol antioxidant compounds (chlorogenic acids for coffee and catechins for tea). The bioavailability of catechins is somewhat known and has been referenced in the literature. However, bioavailability data from tea infusion is non-existent, even though it reflects better how consumers drink this beverage. In addition, bioavailability of coffee chlorogenic acids is less understood and no dose response study has been reported so far in the literature. Thus, there is a great need to understand and reinforce our knowledge on the bioavailability of coffee and tea polyphenol compounds.

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Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Investigators

Study Groups

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High dose coffee

High dose of polyphenols from soluble coffee

Group Type EXPERIMENTAL

Coffee

Intervention Type OTHER

Soluble coffee commercially available

Medium dose coffee

Medium dose of polyphenols from soluble coffee

Group Type EXPERIMENTAL

Coffee

Intervention Type OTHER

Soluble coffee commercially available

Low dose coffee

Low dose of polyphenols from soluble coffee

Group Type EXPERIMENTAL

Coffee

Intervention Type OTHER

Soluble coffee commercially available

High dose green tea

High dose of green tea polyphenols from infusion

Group Type EXPERIMENTAL

Green tea

Intervention Type OTHER

Infusion (tea bags) from commercially available green tea

Medium dose green tea infusion

Medium dose of green polyphenols from infusion

Group Type EXPERIMENTAL

Green tea

Intervention Type OTHER

Infusion (tea bags) from commercially available green tea

Low dose green tea infusion

low dose of polyphenols from an infusion of green tea

Group Type EXPERIMENTAL

Green tea

Intervention Type OTHER

Infusion (tea bags) from commercially available green tea

Interventions

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Green tea

Infusion (tea bags) from commercially available green tea

Intervention Type OTHER

Coffee

Soluble coffee commercially available

Intervention Type OTHER

Other Intervention Names

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Soluble coffee

Eligibility Criteria

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Inclusion Criteria

* 18 - 65 years, male and female
* Healthy as determined by the medical questionnaire and the medical visit
* Normal weight: BMI 18 - 25
* Coffee drinkers with an average consumption of 2-5 cups per day
* Having given informed consent

Exclusion Criteria

* Intestinal or metabolic diseases / disorders such as diabetic, renal, hepatic, hypertension, pancreatic or ulcer
* Have had a gastrointestinal surgery, except appendicectomy
* Difficulty to swallow
* Have a regular consumption of medication
* Have taken antibiotic therapy within the last 6 months
* Alcohol consumption \> 2 units a day
* Smokers (more than 5 cigarettes per day)
* Have given blood within the last 3 weeks
* Volunteers who cannot be expected to comply with treatment
* Currently participating or having participated in another clinical trial during the last 3 weeks

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes