The Effect of High and Low Roasted Coffee on Vascular Response
NCT ID: NCT01813981
Last Updated: 2013-03-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
19 participants
INTERVENTIONAL
2011-05-31
2013-01-31
Brief Summary
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The aim of this study is to investigate the effect of coffee roasting on vascular response. The investigators hypothesize that coffee roasted to a lesser extent will exert a favourable vascular response over more heavily roasted coffee due to the higher levels of CGA.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
PREVENTION
SINGLE
Study Groups
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High roast coffee
110mg caffeine with 108 mg chlorogenic acid at start of study
Control (Caffeine dissolved in water)
Caffeine dissolved in water
Low roast coffee
110 mg caffeine with 235 mg chlorogenic acid at start of the study
Low roast coffee
Instant coffee
Control
110 mg caffeine at start of study
High roast coffee
Instant coffee
Interventions
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Low roast coffee
Instant coffee
High roast coffee
Instant coffee
Control (Caffeine dissolved in water)
Caffeine dissolved in water
Eligibility Criteria
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Inclusion Criteria
* A signed consent form
* Age 19-35 years
* Body mass index - 18.5-30 kg/m2
* Normal blood pressure at screening (\< 150/90)
Exclusion Criteria
* Haemoglobin (anaemia marker) \< 125 g/l
* Gamma GT (liver enzymes) \> 80 IU/l
* Cholesterol \> 6.5 mmol/l
* Had suffered a myocardial infarction or stroke in the previous 12 months
* Suffers from any reproductive disorder
* Suffers from any blood-clotting disorder
* Suffers from any metabolic disorders (e.g. diabetes or any other endocrine or liver diseases)
* Any dietary restrictions or on a weight reducing diet
* Drinking more than 21 units per week
* On any lipid-modifying medication
* On any blood pressure lowering medication
* On any medication affecting blood clotting
* Planning on altering consumption of vitamin supplements/fish oil capsules during the course of the study
* Regular or vigorous exercise (3 times/week, 20 minutes each session)
* Smoking
* Vegetarians or vegans
19 Years
35 Years
MALE
Yes
Sponsors
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University of Reading
OTHER
Responsible Party
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Jeremy Paul Edward Spencer
Professor
Principal Investigators
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Jeremy PE Spencer
Role: PRINCIPAL_INVESTIGATOR
University of Reading
Locations
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Department of Food and Nutritional Sciences
Reading, Berkshire, United Kingdom
University of Reading
Reading, England, United Kingdom
Countries
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References
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Mills CE, Flury A, Marmet C, Poquet L, Rimoldi SF, Sartori C, Rexhaj E, Brenner R, Allemann Y, Zimmermann D, Gibson GR, Mottram DS, Oruna-Concha MJ, Actis-Goretta L, Spencer JPE. Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials. Clin Nutr. 2017 Dec;36(6):1520-1529. doi: 10.1016/j.clnu.2016.11.013. Epub 2016 Nov 30.
Other Identifiers
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COFF2011
Identifier Type: -
Identifier Source: org_study_id
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