The Effects of Caffeine on Heart Rate and Heart Rate Variability

NCT ID: NCT05521386

Last Updated: 2022-08-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

16 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-09-01

Study Completion Date

2023-04-30

Brief Summary

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In previous research we have shown that an acute caffeine dose of 5 mg/kg body mass reduces heart rate at rest and during low intensity exercise, with the effect dissipating as exercise intensity increases. If, as suspected, the effect at rest and at low intensities is due to an effect of caffeine on parasympathetic activity, this is likely to be reflected in an increase in heart rate variability (the beat-to-beat fluctuation in heart rate). The aim of this study is therefore to investigate the effect of caffeine on heart rate and heart rate variability at rest and during submaximal exercise.

Detailed Description

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Conditions

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Caffeine

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Caffeine

caffeine dose of 5 mg per kg of body mass administered orally via a gelatine capsule

Group Type EXPERIMENTAL

Caffeine

Intervention Type DRUG

Single pill in an acute dose of 5 mg per kg of body mass

Placebo

maltodextrin (placebo) dose of 5 mg per kg of body mass administered orally via a gelatine capsule

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Single pill in an acute dose of 5 mg per kg of body mass

Interventions

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Caffeine

Single pill in an acute dose of 5 mg per kg of body mass

Intervention Type DRUG

Placebo

Single pill in an acute dose of 5 mg per kg of body mass

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Trained cyclists

Exclusion Criteria

* Injured or a contraindicative medical condition
Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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St Mary's University College

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

References

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Glaister M, Lythgoe D, Kamath S. The Effects of Caffeine on Heart Rate and Heart Rate Variability at Rest and During Submaximal Cycling Exercise. Res Q Exerc Sport. 2025 Mar;96(1):155-163. doi: 10.1080/02701367.2024.2377303. Epub 2024 Jul 15.

Reference Type DERIVED
PMID: 39008947 (View on PubMed)

Other Identifiers

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StMarysUC5

Identifier Type: -

Identifier Source: org_study_id

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