A Neuropsychological Test Battery for the Assessment of Time Deficits
NCT ID: NCT04419818
Last Updated: 2023-09-25
Study Results
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Basic Information
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COMPLETED
96 participants
OBSERVATIONAL
2019-02-01
2023-01-13
Brief Summary
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The ability to estimate and reproduce time processing is usually evaluated using computerized tasks and it is influenced by aging: young participants overestimate and elderly participants underestimate time durations.
Virtual Reality is an ecological approach that has recently been used for the assessment of cognitive deficits. Here we use Virtual Reality to study the ability to estimate time duration of an action execution and perception in a simulated everyday activity.
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Detailed Description
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Interestingly, recent evidence has begun to demonstrate that our perceptions and sensations are influenced by motor movements and actions. Further, there is also evidence suggesting that movement not only biases perceived time, but can enhance it, suggesting the motor system directly influences temporal perception.
The ability to estimate and reproduce time in actions is usually evaluated using computerized tasks and it is influenced by aging: young participants overestimate and elderly participants underestimate time durations.
Virtual Reality is an ecological approach that has recently been used for the assessment of cognitive deficits. Here we use Virtual Reality to study the ability to estimate time duration of an action execution and perception in a simulated everyday activity.
The primary aim of the project is to measure the impact of time deficits and its effects on everyday life: a neuropsychological battery assessing time processing (Time Estimation, Time Reproduction, Mental Time Travel) is tested using both computerized and virtual reality tasks.
Moreover, the project aims also to investigate i) the correlation between Time Reproduction in a computerized task and the ability to reproduce the duration of an executed action in Virtual Reality; ii) the correlation between Time Estimation in a computerized task and the ability to estimate the duration of an executed action in Virtual Reality.
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Left brain damaged patients
A group of 20 left brain damaged (LBD) patients will perform:
* a computerized test battery to measure time abilities (Mental Time Travel, Time Estimation and Time Reproduction);
* a neuropsychological screening (Mini Mental State Examination and Token Test) to assess inclusion/exclusion criteria;
* questionnaires to evaluate the time needed to execute actions and the ability to locate daily activities in time.
Virtual Reality
Virtual Reality task consists of a 3D computer-generated virtual environment that will be displayed on a desktop VR computer monitor. A joystick will provide the graphical interface for patients by allowing user-friendly exploration of virtual scenarios. Participants will be presented 16 actions, with dynamic simulations of real life situations. They will verbally estimate and reproduce the duration of each previously presented action.
Right brain damaged patients
A group of 20 right brain damaged (RBD) patients will perform:
* a computerized test battery to measure time abilities (Mental Time Travel, Time Estimation and Time Reproduction);
* a neuropsychological screening (Mini Mental State Examination and Token Test) to assess inclusion/exclusion criteria;
* questionnaires to evaluate the time needed to execute actions and the ability to locate daily activities in time.
Virtual Reality
Virtual Reality task consists of a 3D computer-generated virtual environment that will be displayed on a desktop VR computer monitor. A joystick will provide the graphical interface for patients by allowing user-friendly exploration of virtual scenarios. Participants will be presented 16 actions, with dynamic simulations of real life situations. They will verbally estimate and reproduce the duration of each previously presented action.
Healthy controls
A group of 40 (20 young and 20 elderly) healthy controls (HC) will perform:
* a computerized test battery to measure time abilities (Mental Time Travel, Time Estimation and Time Reproduction);
* a neuropsychological screening (Mini Mental State Examination) to assess inclusion/exclusion criteria;
* questionnaires to evaluate the time needed to execute actions and the ability to locate daily activities in time.
Virtual Reality
Virtual Reality task consists of a 3D computer-generated virtual environment that will be displayed on a desktop VR computer monitor. A joystick will provide the graphical interface for patients by allowing user-friendly exploration of virtual scenarios. Participants will be presented 16 actions, with dynamic simulations of real life situations. They will verbally estimate and reproduce the duration of each previously presented action.
Interventions
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Virtual Reality
Virtual Reality task consists of a 3D computer-generated virtual environment that will be displayed on a desktop VR computer monitor. A joystick will provide the graphical interface for patients by allowing user-friendly exploration of virtual scenarios. Participants will be presented 16 actions, with dynamic simulations of real life situations. They will verbally estimate and reproduce the duration of each previously presented action.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* psychiatric disorders
* additional neurological disorders
* abusive use of alcohol or illicit drugs
20 Years
85 Years
ALL
Yes
Sponsors
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University of Bologna
OTHER
Istituti Clinici Scientifici Maugeri SpA
OTHER
Responsible Party
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Principal Investigators
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Francesca Frassinetti, PhD
Role: PRINCIPAL_INVESTIGATOR
Istituti Clinici Scientifici Maugeri IRCCS
Locations
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ICS Maugeri IRCCS, U.O. di Rieducazione e Recupero funzionale di Castel Goffredo
Castel Goffredo, Mantova, Italy
Countries
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References
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Anelli F, Avanzi S, Arzy S, Mancuso M, Frassinetti F. Effects of spatial attention on mental time travel in patients with neglect. Cortex. 2018 Apr;101:192-205. doi: 10.1016/j.cortex.2018.01.012. Epub 2018 Feb 2.
Anelli F, Avanzi S, Damora A, Mancuso M, Frassinetti F. Mental time travel and functional daily life activities in neglect patients: Recovery effects of rehabilitation by prism adaptation. Cortex. 2019 Apr;113:141-155. doi: 10.1016/j.cortex.2018.12.003. Epub 2018 Dec 14.
De Renzi E, Faglioni P. Normative data and screening power of a shortened version of the Token Test. Cortex. 1978 Mar;14(1):41-9. doi: 10.1016/s0010-9452(78)80006-9.
Della Sala S, MacPherson SE, Phillips LH, Sacco L, Spinnler H. How many camels are there in Italy? Cognitive estimates standardised on the Italian population. Neurol Sci. 2003 Apr;24(1):10-5. doi: 10.1007/s100720300015.
Demeurisse G, Demol O, Robaye E. Motor evaluation in vascular hemiplegia. Eur Neurol. 1980;19(6):382-9. doi: 10.1159/000115178.
Espinosa-Fernandez L, Miro E, Cano M, Buela-Casal G. Age-related changes and gender differences in time estimation. Acta Psychol (Amst). 2003 Mar;112(3):221-32. doi: 10.1016/s0001-6918(02)00093-8.
Folstein MF, Folstein SE, McHugh PR. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975 Nov;12(3):189-98. doi: 10.1016/0022-3956(75)90026-6. No abstract available.
Frassinetti F, Magnani B, Oliveri M. Prismatic lenses shift time perception. Psychol Sci. 2009 Aug;20(8):949-54. doi: 10.1111/j.1467-9280.2009.02390.x. Epub 2009 Jun 22.
Patane I, Farne A, Frassinetti F. Prismatic Adaptation Induces Plastic Changes onto Spatial and Temporal Domains in Near and Far Space. Neural Plast. 2016;2016:3495075. doi: 10.1155/2016/3495075. Epub 2016 Feb 14.
Wiener M, Zhou W, Bader F, Joiner WM. Movement Improves the Quality of Temporal Perception and Decision-Making. eNeuro. 2019 Aug 20;6(4):ENEURO.0042-19.2019. doi: 10.1523/ENEURO.0042-19.2019. Print 2019 Jul/Aug.
Cantarella G, Vianello G, Vezzadini G, Frassinetti F, Ciaramelli E, Candini M. Time bisection and reproduction: Evidence for a slowdown of the internal clock in right brain damaged patients. Cortex. 2023 Oct;167:303-317. doi: 10.1016/j.cortex.2023.05.024. Epub 2023 Jul 25.
Other Identifiers
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ICS Maugeri CE 2194-Ob2B
Identifier Type: -
Identifier Source: org_study_id
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