Anxiety and Fear of Cancer Before and After Banding Without Resection in Small SET Management (QUALI-BANDING-SET)

NCT ID: NCT04316000

Last Updated: 2021-09-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

SUSPENDED

Total Enrollment

150 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-11-22

Study Completion Date

2022-03-31

Brief Summary

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To analyze the hypothetical improvement in anxiety degree, quality of life and fear of cancer in patients diagnosed with a small gastrointestinal subeptithelial tumor when opting for the removal of the lesion.

Detailed Description

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This "Quality of Life" study is directly related to the "BANDING-SET" study (NCT03247231), whose main aim is to analyze the effectiveness and safety of endoscopic band ligation without resection in the small gastrointestinal subepithelial tumours management.

Using three validated tests (Hospital Anxiety and Depression Scale \[HADS\], Cancer Worry Scale \[CWS\] and European Five-Dimension Quality of Live test \[EuroQol-5D\]) patients are evaluated before and after the endoscopic procedure.

Three main groups of patients are presented:

* GROUP A, in which the subephitelial tumour is successfully removed \[hypothesis: anxiety and fear of cancer should decrease\].
* GROUP B, in which the subephitelial tumour is not successfully removed due to various reasons (size \>15-mm, not technical success,...) \[hypothesis: anxiety and fear of cancer shuold be similar before-after\].
* GROUP C, in which the subephitelial tumour is not observed or is a benign entity, which does not require further interventions for these patients \[hypothesis: anxiety and fear of cancer should decrease\].

Conditions

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Gastrointestinal Subepithelial Tumors

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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A - Removal of the Subepithelial Tumour

The subephitelial tumour is successfully removed by endoscopic band ligation without resection.

Initial Anxiety and Fear of Cancer Test

Intervention Type OTHER

Answer to Hospital Anxiety and Depression Scale (HADS), Cancer Worry Scale (CWS) and European Five-Dimension Quality of Live test (EuroQol-5D) before the initial endoscopic procedure.

Endoscopic band ligation without resection of the subpetihelial tumour.

Intervention Type PROCEDURE

Correct application of the elastic band in the subepithelial tumor, achieving its removal by self-amputation in the 4-6 weeks endoscopic ultrasonography (EUS) control.

1-2 Months Anxiety and Fear of Cancer Test

Intervention Type OTHER

Answer to Hospital Anxiety and Depression Scale (HADS), Cancer Worry Scale (CWS) and European Five-Dimension Quality of Live test (EuroQol-5D) after 1-2 months of the initial endoscopic procedure, knowing whether the tumor has either been removed or not, is a benign entity or has not been observed.

1 Year Anxiety and Fear of Cancer Test

Intervention Type OTHER

Answer to Hospital Anxiety and Depression Scale (HADS), Cancer Worry Scale (CWS) and European Five-Dimension Quality of Live test (EuroQol-5D) after 1 year of the initial endoscopic procedure, knowing whether the tumor has either been removed or not.

B - Non Removal of the Subepithelial Tumour

The subephitelial tumour is not successfully removed due to various reasons (size \>15-mm, not technical success,...).

Initial Anxiety and Fear of Cancer Test

Intervention Type OTHER

Answer to Hospital Anxiety and Depression Scale (HADS), Cancer Worry Scale (CWS) and European Five-Dimension Quality of Live test (EuroQol-5D) before the initial endoscopic procedure.

1-2 Months Anxiety and Fear of Cancer Test

Intervention Type OTHER

Answer to Hospital Anxiety and Depression Scale (HADS), Cancer Worry Scale (CWS) and European Five-Dimension Quality of Live test (EuroQol-5D) after 1-2 months of the initial endoscopic procedure, knowing whether the tumor has either been removed or not, is a benign entity or has not been observed.

1 Year Anxiety and Fear of Cancer Test

Intervention Type OTHER

Answer to Hospital Anxiety and Depression Scale (HADS), Cancer Worry Scale (CWS) and European Five-Dimension Quality of Live test (EuroQol-5D) after 1 year of the initial endoscopic procedure, knowing whether the tumor has either been removed or not.

C - Not Observed or Benign Subepithelial Tumour

The subephitelial tumour is not observed or is a benign entity, which does not require further interventions for these patients.

Initial Anxiety and Fear of Cancer Test

Intervention Type OTHER

Answer to Hospital Anxiety and Depression Scale (HADS), Cancer Worry Scale (CWS) and European Five-Dimension Quality of Live test (EuroQol-5D) before the initial endoscopic procedure.

1-2 Months Anxiety and Fear of Cancer Test

Intervention Type OTHER

Answer to Hospital Anxiety and Depression Scale (HADS), Cancer Worry Scale (CWS) and European Five-Dimension Quality of Live test (EuroQol-5D) after 1-2 months of the initial endoscopic procedure, knowing whether the tumor has either been removed or not, is a benign entity or has not been observed.

Interventions

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Initial Anxiety and Fear of Cancer Test

Answer to Hospital Anxiety and Depression Scale (HADS), Cancer Worry Scale (CWS) and European Five-Dimension Quality of Live test (EuroQol-5D) before the initial endoscopic procedure.

Intervention Type OTHER

Endoscopic band ligation without resection of the subpetihelial tumour.

Correct application of the elastic band in the subepithelial tumor, achieving its removal by self-amputation in the 4-6 weeks endoscopic ultrasonography (EUS) control.

Intervention Type PROCEDURE

1-2 Months Anxiety and Fear of Cancer Test

Answer to Hospital Anxiety and Depression Scale (HADS), Cancer Worry Scale (CWS) and European Five-Dimension Quality of Live test (EuroQol-5D) after 1-2 months of the initial endoscopic procedure, knowing whether the tumor has either been removed or not, is a benign entity or has not been observed.

Intervention Type OTHER

1 Year Anxiety and Fear of Cancer Test

Answer to Hospital Anxiety and Depression Scale (HADS), Cancer Worry Scale (CWS) and European Five-Dimension Quality of Live test (EuroQol-5D) after 1 year of the initial endoscopic procedure, knowing whether the tumor has either been removed or not.

Intervention Type OTHER

Other Intervention Names

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Initial Test Successful SET banding 1-2 Months Test 1 Year Test

Eligibility Criteria

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Inclusion Criteria

* Age between 18 and 80 years.
* Patient able to sign and understand the Informed Consent.
* Patient with a previously corroborated diagnosis of a subepithelial tumor (SET) by previous endoscopic ultrasonography (EUS), or possible diagnosis of SET by finding a subepithelial lesion (SEL) in a conventional endoscopy performed that will require a EUS study.
* Acceptance by the patient as a candidate of the BANDING-SET study (NCT03247231) of assessment of the effectiveness and safety of band ligation without resection of subepithelial tumors of the digestive tract ≤15-mm, with the prior signing of the Informed Consent of this study.
* Patient that understand the concept of the study and will complete all the time frame until the study end

Exclusion Criteria

* No Informed Consent.
* No BANDING-SET study (NCT03247231) Informed Consent.
* Patients with functional diversity, unable to understand the nature and possible consequences of the study.
* Patients unable to maintain subsequent follow-up (lack of adherence).
* Patients with a life expectancy of less than 12 months.
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Francesc Bas-Cutrina

OTHER

Sponsor Role lead

Responsible Party

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Francesc Bas-Cutrina

Principal Investigator

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Francesc Bas-Cutrina, MD

Role: PRINCIPAL_INVESTIGATOR

Endoscopy Unit; Digestive Diseases Department; H. Universitari de Bellvitge.

Joan B Gornals, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Endoscopy Unit; Digestive Diseases Department; H. Universitari de Bellvitge.

Sebastià Videla, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Department of Clinical Pharmacology; H. Universitari de Bellvitge.

Locations

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Hospital Universitari Germans Trias i Pujol (Can Ruti)

Badalona, Barcelona, Catalonia, Spain

Site Status

Hospital Universitari de Bellvitge

L'Hospitalet de Llobregat, Barcelona, Catalonia, Spain

Site Status

Hospital Universitari Mútua de Terrassa

Terrassa, Barcelona, Catalonia, Spain

Site Status

Hospital de Sant Pau i de la Santa Creu

Barcelona, Catalonia, Spain

Site Status

Hospital Universitari de Girona Doctor Josep Trueta

Girona, Catalonia, Spain

Site Status

Hospital Universitari Arnau de Vilanova de Lleida

Lleida, Catalonia, Spain

Site Status

Hospital Universitari Joan XXIII de Tarragona

Tarragona, Catalonia, Spain

Site Status

Countries

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Spain

References

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Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983 Jun;67(6):361-70. doi: 10.1111/j.1600-0447.1983.tb09716.x.

Reference Type RESULT
PMID: 6880820 (View on PubMed)

Herdman M, Badia X, Berra S. [EuroQol-5D: a simple alternative for measuring health-related quality of life in primary care]. Aten Primaria. 2001 Oct 15;28(6):425-30. doi: 10.1016/s0212-6567(01)70406-4. No abstract available. Spanish.

Reference Type RESULT
PMID: 11602124 (View on PubMed)

Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, Filiberti A, Flechtner H, Fleishman SB, de Haes JC, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993 Mar 3;85(5):365-76. doi: 10.1093/jnci/85.5.365.

Reference Type RESULT
PMID: 8433390 (View on PubMed)

Other Identifiers

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QUALI-BANDING-SET

Identifier Type: -

Identifier Source: org_study_id

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