Brain-Induced Neurotrophic Factor Levels in Patients Undergoing Coronary Artery Bypass Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

45 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-01-15

Study Completion Date

2020-10-15

Brief Summary

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In patients undergoing coronary artery bypass surgery, the relationship between neurocognitive changes seen in the early period and brain-induced neurotrophic factor serum levels will be investigated.

Detailed Description

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Although postoperative cognitive dysfunction (POKD) is the most common neurological complication in patients undergoing coronary artery bypass grafting (CABG) surgery, its pathophysiology is still not fully understood. However, the quality of this dysfunction has not been properly measured. In addition to clinical tests, biomarkers are often used to detect the presence of POKD. In this study, it was aimed to evaluate the relationship between intraoperative and postoperative brain-derived neurotrophic factor serum levels and POKD in patients undergoing CABG surgery.

This prospective observational study is planned to include 30 adult patients aged 40-90 years. Patients with stroke history, neurodegenerative disease, seizure history, alcohol use, general anxiety, hearing deficit, unilateral carotid artery stenosis greater than 70%, and carotid artery bilateral stenosis greater than 50% will be excluded from the study.

This study aimed to determine perioperative changes in serum brain-derived neurotrophic factor levels in patients undergoing CABG surgery.

Conditions

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Cognitive Dysfunction

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Interventions

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Patients with cognitive dysfunction

Mini Mental Test Those with a score below 21 points

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* At Least Primary School Graduates,
* Not Using Drugs That May Affect Cognitive Functions,
* No Alcohol Substance Use,
* Without Psychiatric And Neurological Diseases

Exclusion Criteria

* Uneducated Patients,
* Drug Users Who May Affect Cognitive Functions (Antipsychotic, Antidepressant),
* Have Alcohol And Substance Use Disorders,
* Those With A History Of Central Nervous System Disease That May Cause Cognitive Dysfunction (Such As Stroke, Neurodegenerative Disease, Seizure, General Anxiety),
* Hearing Deficit,
* Patients With Unilateral Carotid Artery Stenosis Greater Than 70% And Bilateral Stenosis Greater than 50% Carotid Artery

Minimum Eligible Age

40 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Ökkeş Hakan Miniksar

Asist.Prof.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Yozgat Bozok University Research Hospital

Role: STUDY_DIRECTOR

Yozgat

Locations

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Bozok University Medical Center

Yozgat, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

References

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Miniksar OH, Cicekcioglu F, Kilic M, Honca M, Miniksar DY, Gocmen AY, Kacmaz O, Oz H. Decreased brain-derived neurotrophic factor levels may predict early perioperative neurocognitive disorder in patients undergoing coronary artery bypass surgery: A prospective observational pilot study. J Clin Anesth. 2021 Aug;71:110235. doi: 10.1016/j.jclinane.2021.110235. Epub 2021 Mar 25.

Reference Type DERIVED

PMID: 33774438 (View on PubMed)

Other Identifiers

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20194466

Identifier Type: -

Identifier Source: org_study_id