A Study of HD-tDCS and Cognitive Training to Improve Cognitive Function in MCI
NCT ID: NCT04246164
Last Updated: 2026-01-28
Study Results
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View full resultsBasic Information
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COMPLETED
NA
8 participants
INTERVENTIONAL
2021-01-25
2023-02-23
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
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HD-tDCS combined with CT
HD-tDCS combined with CT, administered to participants with amnestic MCI (aMCI) in blocks of 5 daily treatments for a total of 15 sessions. There will be one treatment block/month for a total of 3 months
HD-tDCS combined with CT
HD-tDCS treatments will be administered during a cognitive training session.
sham HD-tDCS combined with CT
sham HD-tDCS combined with CT, administered to participants with amnestic MCI (aMCI) in blocks of 5 daily treatments for a total of 15 sessions. There will be one treatment block/month for a total of 3 months
sham HD-tDCS combined with CT
sham-HD-tDCS treatments will be administered during a cognitive training session.
Interventions
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HD-tDCS combined with CT
HD-tDCS treatments will be administered during a cognitive training session.
sham HD-tDCS combined with CT
sham-HD-tDCS treatments will be administered during a cognitive training session.
Eligibility Criteria
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Inclusion Criteria
2. Willing and able to undergo all procedures
3. Retains decisional capacity at initial visit
4. Meets criteria for MCI, amnestic type (Petersen, 2004).
Exclusion Criteria
2. Automatic Internal Cardiac Defibrillator (AICD) or Pacemaker
3. Significant congestive heart failure
4. History of clinically significant ischemic or hemorrhagic stroke, or lacune or infarct considered by radiologist likely to cause or contribute significantly to cognitive symptoms
5. History of thalamic lacunar stroke
6. Modified Hachinski Ischemia Score \>4 points
7. History of seizure disorder requiring medication
8. History of brain surgery (for seizure disorder, aneurysms, or benign/malignant tumor)
9. History of HIV/AIDS
10. Severe untreated obstructive sleep apnea
11. Greater than three servings alcohol daily or illicit drug use
12. Major neurologic disorders other than dementia (e.g., MS, ALS)
13. Schizophrenia, bipolar disorder, other serious mental illnesses
14. Other significant medical conditions at investigators' discretion
15. Pregnancy
16. Lack of study partner (Participants are allowed to find a new study partner if the original study partner withdraws)
50 Years
90 Years
ALL
No
Sponsors
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University of Wisconsin, Madison
OTHER
Medical College of Wisconsin
OTHER
Responsible Party
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Priyanka Shah-Basak, PhD
Assistant Professor of Neurology
Locations
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The Medical College of Wisconsin
Milwaukee, Wisconsin, United States
Countries
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Provided Documents
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Document Type: Study Protocol and Statistical Analysis Plan
Document Type: Informed Consent Form
Other Identifiers
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PRO00035757
Identifier Type: -
Identifier Source: org_study_id
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