Modulation of Visual-Spatial Learning in Patients With Mild Cognitive Impairment (MCI) by tDCS

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

21 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-03-31

Study Completion Date

2017-10-31

Brief Summary

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The aim of this study is to investigate whether a combination of intensive training of visual-spatial abilities (LOCATO task) with anodal transcranial direct current stimulation (tDCS) leads to an improvement in learning and memory in patients with mild cognitive impairment (MCI) and to examine the underlying neuronal mechanism.

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Detailed Description

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Conditions

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Mild Cognitive Impairment (MCI)

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Caregivers

Study Groups

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training + tDCS

Combination of intensive training of visual-spatial abilities (LOCATO task) with anodal transcranial direct current stimulation (tDCS)

Group Type EXPERIMENTAL

tDCS

Intervention Type DEVICE

transcranial direct current stimulation (tDCS)

training

Intervention Type BEHAVIORAL

intensive training of visual-spatial abilities (in LOCATO task)

training + sham stimulation

Combination of intensive training of visual-spatial abilities (LOCATO task) with sham stimulation

Group Type SHAM_COMPARATOR

tDCS

Intervention Type DEVICE

transcranial direct current stimulation (tDCS)

training

Intervention Type BEHAVIORAL

intensive training of visual-spatial abilities (in LOCATO task)

Interventions

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tDCS

transcranial direct current stimulation (tDCS)

Intervention Type DEVICE

training

intensive training of visual-spatial abilities (in LOCATO task)

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* right handedness
* amnestic and amnestic plus MCI with:

1. subjective memory impairment;
2. objective memory difficulties, at least 1 SD below gender, age and education adjusted standard values;
3. relatively normal performance in other cognitive domains;
4. no constraints in activities of daily livings
5. age: 50-90 years

Exclusion Criteria

* severe internal or psychiatric disease
* epilepsy
* other severe neurological diseases, e.g. previous major stroke or brain tumor
* DMS-IV manifest dementia
* contraindication for MRT (claustrophobia, metallic implants, tattoos)

Minimum Eligible Age

50 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No