Transcranial Direct Current Stimulation to Enhance Cognition in Mild Cognitive Impairment

NCT ID: NCT01653431

Last Updated: 2020-02-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1/PHASE2

Total Enrollment

68 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-01-31

Study Completion Date

2019-11-01

Brief Summary

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The study will examine whether the effects of computerized brain training are enhanced when training is combined with mild brain stimulation in patients with mild cognitive impairment. We hypothesize that this combination will produce greater improvements in cognitive functioning than computerized brain training alone.

Detailed Description

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Conditions

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Mild Cognitive Impairment

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Transcranial direct current stimulation

Transcranial direct current stimulation combined with cognitive training

Group Type EXPERIMENTAL

Transcranial direct current stimulation

Intervention Type DEVICE

Sham transcranial direct current stimulation

Sham transcranial direct current stimulation combined with cognitive training

Group Type SHAM_COMPARATOR

Transcranial direct current stimulation

Intervention Type DEVICE

Interventions

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Transcranial direct current stimulation

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Aged 60 - 85 years.
* Meet diagnostic criteria for amnestic mild cognitive impairment.

Exclusion Criteria

* Inability to provide informed consent.
* Concurrent medication likely to affect mental performance.
* Current substance use or dependence in last 3 months.
* Current active psychiatric or neurological condition
Minimum Eligible Age

60 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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The University of New South Wales

OTHER

Sponsor Role lead

Responsible Party

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Melissa Pigot

Research Assistant

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Black Dog Institute

Sydney, New South Wales, Australia

Site Status

Countries

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Australia

References

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Martin DM, Mohan A, Alonzo A, Gates N, Gbadeyan O, Meinzer M, Sachdev P, Brodaty H, Loo C. A Pilot Double-Blind Randomized Controlled Trial of Cognitive Training Combined with Transcranial Direct Current Stimulation for Amnestic Mild Cognitive Impairment. J Alzheimers Dis. 2019 Aug 12;71(2):503-512. doi: 10.3233/JAD-190306.

Reference Type DERIVED
PMID: 31424410 (View on PubMed)

Other Identifiers

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HC12381

Identifier Type: -

Identifier Source: org_study_id

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