Cognitive Ability Training for Seniors With Mild Cognitive Impairment
NCT ID: NCT02940457
Last Updated: 2020-05-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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WITHDRAWN
NA
INTERVENTIONAL
2017-11-01
2020-12-31
Brief Summary
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Detailed Description
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All test participants train over 6 sessions within 2 weeks two different working memory tasks with increasing difficulty. In the randomized, double-blind, prospective therapy study, participants are assigned to either a Verum-tDCS or a placebo-tDCS group. The Verum-tDCS group receives active stimulation in parallel to the exercise therapy, while the placebo group does not receive tDCS stimulation. To check the effects of the therapy, we measure performance and neuronal activation in different executive tasks using near-infrared spectroscopy (NIRS). Furthermore, we will check whether the training increases the volume of the grey matter (Draganski et al., 2004, Malchow et al., 2016) and the expression of BDNF can be increased (Schuch et al., 2015).
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Verum tDCS
prefrontal anodal stimulation
Verum tDCS
Neuropsychological (working memory) training for 30 minutes, 6 sessions tDCS during training with 2 mA
Sham tDCS
sham stimulation, same electrode positions
Sham tDCS
Neuropsychological (working memory) training for 30 minutes, 6 sessions tDCS during training with 0 mA
Interventions
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Verum tDCS
Neuropsychological (working memory) training for 30 minutes, 6 sessions tDCS during training with 2 mA
Sham tDCS
Neuropsychological (working memory) training for 30 minutes, 6 sessions tDCS during training with 0 mA
Eligibility Criteria
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Inclusion Criteria
* total CERAD score \<= 85.1
* MMSE \>=24
* native german speaker
* between 50-75 years old
* right handed
Exclusion Criteria
* psychiatric, neurological diseases
* uncorrected hearing or vision deficits
* actual psychopharmaca intake
* metal parts in the head
* medical electronical implants
50 Years
75 Years
ALL
No
Sponsors
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Wuerzburg University Hospital
OTHER
Responsible Party
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Principal Investigators
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Martin Herrmann
Role: PRINCIPAL_INVESTIGATOR
Wuerzburg University Hospital
Locations
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University Hospital
Würzburg, , Germany
Countries
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Other Identifiers
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Wuerzburg165/16
Identifier Type: -
Identifier Source: org_study_id
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